en
Scientific article
Open access
English

An injectable meta-biomaterial : from design and simulation to in vivo shaping and tissue induction

Published inAdvanced materials, vol. 33, no. 41, e2102350
Publication date2021-10
First online date2021-08-27
Abstract

A novel type of injectable biomaterial with an elastic softening transition is described. The material enables in vivo shaping, followed by induction of 3D stable vascularized tissue. The synthesis of the injectable meta-biomaterial is instructed by extensive numerical simulation as a suspension of irregularly fragmented, highly porous sponge-like microgels. The irregular particle shape dramatically enhances yield strain for in vivo stability against deformation. Porosity of the particles, along with friction between internal surfaces, provides the elastic softening transition. This emergent metamaterial property enables the material to reversibly change stiffness during deformation, allowing native tissue properties to be matched over a wide range of deformation amplitudes. After subcutaneous injection in mice, predetermined shapes can be sculpted manually. The 3D shape is maintained during excellent host tissue integration, with induction of vascular connective tissue that persists to the end of one-year follow-up. The geometrical design is compatible with many hydrogel materials, including cell-adhesion motives for cell transplantation. The injectable meta-biomaterial therefore provides new perspectives in soft tissue engineering and regenerative medicine.

eng
Keywords
  • Elastic softening
  • Injectable metamaterials
  • Shaping
  • Tissue reconstruction
  • Vascularization
  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism
  • Cell Adhesion
  • Elastic Modulus
  • Female
  • Hydrogels / chemistry
  • Materials Testing
  • Mice
  • Porosity
  • Regenerative Medicine
  • Tissue Engineering
Citation (ISO format)
BEDUER, Amélie et al. An injectable meta-biomaterial : from design and simulation to in vivo shaping and tissue induction. In: Advanced materials, 2021, vol. 33, n° 41, p. e2102350. doi: 10.1002/adma.202102350
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Identifiers
ISSN of the journal0935-9648
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