Model for the pharmacological basis of spontaneous synchronous activity in developing retinas
ContributorsBurgi, Pierre-Yves![orcid](assets/images/orcid.png)
; Grzywacz, Norberto M.
![orcid](assets/images/orcid.png)
Published inThe Journal of neuroscience, vol. 14, no. 12, p. 7426-7439
Publication date1994
Abstract
Keywords
- Aging/physiology
- Animals
- Cesium/pharmacology
- Cobalt/pharmacology
- Computer Simulation
- Electrophysiology
- Humans
- Models, Neurological
- Potassium Channel Blockers
- Retina/drug effects/growth & development/physiology
- Retinal Ganglion Cells/physiology
- Tetraethylammonium
- Tetraethylammonium Compounds/pharmacology
NoteCover picture (Supplemental data): Computer simulations of spontaneous waves of bursty activity propagating through the ganglion cell layer of developing retinas. The simultaneous activation of two spatially separated groups of ganglion cells at the layer's border results in colliding and annihilating waves. The extracellular potassium concentration, shown in the first sequence of frames, rises up to 10 mM, following extrusion of this ion from the bursting cells. This concentration is about four times the resting concentration, visible in green. Such increase in potassium concentration depolarizes neighbor ganglion cells, causing them to fire (and to real ease more potassium) as shown in the second sequence of frames. Time step between frames is 1 sec, and the corresponding physical dimensions of this 241 ganglion cell layer are 364 um for the width and 240 um for the height. See Burgi and Grzywacz, pp. 7426-7439.
Affiliation Not a UNIGE publication
Citation (ISO format)
BURGI, Pierre-Yves, GRZYWACZ, Norberto M. Model for the pharmacological basis of spontaneous synchronous activity in developing retinas. In: The Journal of neuroscience, 1994, vol. 14, n° 12, p. 7426–7439.
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Article (Published version)
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Identifiers
- PID : unige:17443
- PMID : 7996185
ISSN of the journal0270-6474