en
Scientific article
Review
Open access
English

Transport of macromolecules between the nucleus and the cytoplasm

Published inRNA, vol. 4, no. 4, p. 351-364
Publication date1998-04
Abstract

Nuclear transport is an energy-dependent process mediated by saturable receptors. Import and export receptors are thought to recognize and bind to nuclear localization signals or nuclear export signals, respectively, in the transported molecules. The receptor-substrate interaction can be direct or mediated by an additional adapter protein. The transport receptors dock their cargoes to the nuclear pore complexes (NPC) and facilitate their translocation through the NPC. After delivering their cargoes, the receptors are recycled to initiate additional rounds of transport. Because a transport event for a cargo molecule is unidirectional, the transport receptors engage in asymmetric cycles of translocation across the NPC. The GTPase Ran acts as a molecular switch for receptor-cargo interaction and imparts directionality to the transport process. Recently, the combined use of different in vitro and in vivo approaches has led to the characterization of novel import and export signals and to the identification of the first nuclear import and export receptors.

eng
Keywords
  • Biological Transport
  • Carrier Proteins / metabolism
  • Cell Compartmentation
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • GTP Phosphohydrolases / metabolism
  • Models, Biological
  • Nuclear Localization Signals
  • Nuclear Proteins / metabolism
  • Proteins / metabolism
  • RNA / metabolism
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Ran GTP-Binding Protein
Citation (ISO format)
IZAURRALDE, Elisa, ADAM, Stephen. Transport of macromolecules between the nucleus and the cytoplasm. In: RNA, 1998, vol. 4, n° 4, p. 351–364.
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1355-8382
20views
2downloads

Technical informations

Creation12/15/2023 8:51:14 AM
First validation12/15/2023 11:41:18 AM
Update time12/15/2023 11:41:18 AM
Status update12/15/2023 11:41:18 AM
Last indexation01/18/2024 1:52:25 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack