Scientific article
Open access

Effects of a Multimodal Transitional Care Intervention in Patients at High Risk of Readmission

Published inJAMA internal medicine, vol. 183, no. 7, p. 658-668
Publication date2023-07
First online date2023-05-01

Importance: Hospital readmissions are frequent, costly, and sometimes preventable. Although these issues have been well publicized and incentives to reduce them introduced, the best interventions for reducing readmissions remain unclear.

Objectives: To evaluate the effects of a multimodal transitional care intervention targeting patients at high risk of hospital readmission on the composite outcome of 30-day unplanned readmission or death.

Design, setting, and participants: A single-blinded, multicenter randomized clinical trial was conducted from April 2018 to January 2020, with a 30-day follow-up in 4 medium-to-large-sized teaching hospitals in Switzerland. Participants were consecutive patients discharged from general internal medicine wards and at higher risk of unplanned readmission based on their simplified HOSPITAL score (≥4 points). Data were analyzed between April and September 2022.

Interventions: The intervention group underwent systematic medication reconciliation, a 15-minute patient education session with teach-back, a planned first follow-up visit with their primary care physician, and postdischarge follow-up telephone calls from the study team at 3 and 14 days. The control group received usual care from their hospitalist, plus a 1-page standard study information sheet.

Main outcomes and measures: Thirty-day postdischarge unplanned readmission or death.

Results: A total of 1386 patients were included with a mean (SD) age of 72 (14) years; 712 (51%) were male. The composite outcome of 30-day unplanned readmission or death was 21% (95% CI, 18% to 24%) in the intervention group and 19% (95% CI, 17% to 22%) in the control group. The intention-to-treat analysis risk difference was 1.7% (95% CI, -2.5% to 5.9%; P = .44). There was no evidence of any intervention effects on time to unplanned readmission or death, postdischarge health care use, patient satisfaction with the quality of their care transition, or readmission costs.

Conclusions and relevance: In this randomized clinical trial, use of a standardized multimodal care transition intervention targeting higher-risk patients did not significantly decrease the risks of 30-day postdischarge unplanned readmission or death; it demonstrated the difficulties in preventing hospital readmissions, even when multimodal interventions specifically target higher-risk patients.

Trial registration: ClinicalTrials.gov Identifier: NCT03496896.

  • Aftercare
  • Aged
  • Female
  • Hospitals, Teaching
  • Humans
  • Male
  • Patient Discharge
  • Patient Readmission
  • Transitional Care
Citation (ISO format)
DONZÉ, Jacques et al. Effects of a Multimodal Transitional Care Intervention in Patients at High Risk of Readmission. In: JAMA internal medicine, 2023, vol. 183, n° 7, p. 658–668. doi: 10.1001/jamainternmed.2023.0791
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Article (Published version)
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ISSN of the journal2168-6106

Technical informations

Creation06/01/2023 9:37:42 AM
First validation11/20/2023 1:24:55 PM
Update time11/20/2023 1:24:55 PM
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