Scientific article
Open access

Dual-energy computed tomography to detect early pulmonary vascular changes in children with sickle cell disease: a pilot study

Published inFrontiers in pediatrics, vol. 11, 1221977
First online date2023-08-30

Introduction: Pulmonary hypertension (PH) is a rare but fatal complication of sickle cell disease (SCD) that is possibly reversible if treated early. Dual-energy computed tomography (DECT) is a valuable tool for diagnosing PH. We attempted to determine if DECT can detect early signs of PH in children with SCD.

Methods: This prospective observational pilot study was conducted at the Geneva University Hospitals and was approved by the local human ethics committee (CCER 2019-01975). A written informed consent was obtained from the patients and/or their legal guardian. Eight children (consisting of five girls and three boys) with homozygous SCD were included in the study. They underwent full cardiological workup using transthoracic echocardiography (TTE) and cardiopulmonary exercise test (CPET), as well as DECT.

Results: The median age of the children was 11 years old (range 8-12). All patients exhibited a normal biventricular systo-diastolic function using the TTE. The median tricuspid regurgitant jet velocity value was 2.24 m/s (range 1.96-2.98). Four children were found to have signs of vasculopathy detected on DECT. Of them, two had abnormal screening test results. They both had an increased VE/VCO2slope during CPET and an increased TVR of >2.5 m/s on TTE.

Conclusion: DECT is capable of identifying early signs of pulmonary vascular disease in children with SCD. Further studies are needed to understand the correlation between DECT abnormalities and hemodynamic pulmonary circulation better.

  • Children
  • Dual-energy computed tomography
  • Pulmonary hypertension
  • Screening
  • Sickle cell disease
Citation (ISO format)
JOYE, Raphaël et al. Dual-energy computed tomography to detect early pulmonary vascular changes in children with sickle cell disease: a pilot study. In: Frontiers in pediatrics, 2023, vol. 11, p. 1221977. doi: 10.3389/fped.2023.1221977
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ISSN of the journal2296-2360

Technical informations

Creation10/20/2023 2:17:05 PM
First validation11/16/2023 7:57:09 AM
Update time11/16/2023 7:57:09 AM
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