Scientific article

Hormonal therapy for oestrogen receptor-negative breast cancer is associated with higher disease-specific mortality

Published inAnnals of oncology, vol. 20, no. 5, p. 857-861
Publication date2009

BACKGROUND: Tamoxifen has a remarkable impact on the outcome of oestrogen receptor (ER)-positive breast cancer. Without proven benefits, tamoxifen is occasionally prescribed for women with ER-negative disease. This population-based study aims to estimate the impact of tamoxifen on the outcome of ER-negative disease. METHODS: We identified all women (n = 528) diagnosed with ER-negative invasive breast cancer between 1995 and 2005. With Cox regression analysis, we calculated breast cancer mortality risks of patients treated with tamoxifen compared with those treated without tamoxifen. We adjusted these risks for the individual probabilities (propensity scores) of having received tamoxifen. RESULTS: Sixty-nine patients (13%) with ER-negative disease were treated with tamoxifen. Five-year disease-specific survival for women treated with versus without tamoxifen were 62% [95% confidence interval (CI) 48% to 76%] and 79% (95% CI 75% to 83%), respectively (P(Log-rank) < 0.001). For ER-negative patients, risk of death from breast cancer was significantly increased in those treated with tamoxifen compared with patients treated without tamoxifen (adjusted hazard ratio = 1.7, 95% CI 1.1-2.9, P = 0.031). CONCLUSION: Our results show that patients with ER-negative breast cancer treated with tamoxifen have an increased risk of death from their disease. Tamoxifen use should be avoided for these patients.

Citation (ISO format)
MERGLEN, Arnaud et al. Hormonal therapy for oestrogen receptor-negative breast cancer is associated with higher disease-specific mortality. In: Annals of oncology, 2009, vol. 20, n° 5, p. 857–861. doi: 10.1093/annonc/mdn688
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Article (Accepted version)
ISSN of the journal0923-7534

Technical informations

Creation05/26/2009 10:30:00 AM
First validation05/26/2009 10:30:00 AM
Update time03/14/2023 3:05:30 PM
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