Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
Contributeurs/tricesPlum, Leona; Ma, Xiaosong; Hampel, Brigitte; Balthasar, Nina; Coppari, Roberto; Münzberg, Heike; Shanabrough, Marya; Burdakov, Denis![orcid](assets/images/orcid.png)
; Rother, Eva; Janoschek, Ruth![orcid](assets/images/orcid.png)
; Alber, Jens; Belgardt, Bengt F; Koch, Linda![orcid](assets/images/orcid.png)
; Seibler, Jost; Schwenk, Frieder; Fekete, Csaba![orcid](assets/images/orcid.png)
; Suzuki, Akira![orcid](assets/images/orcid.png)
; Mak, Tak W; Krone, Wilhelm; Horvath, Tamas L; Ashcroft, Frances M; Brüning, Jens C
![orcid](assets/images/orcid.png)
![orcid](assets/images/orcid.png)
![orcid](assets/images/orcid.png)
![orcid](assets/images/orcid.png)
![orcid](assets/images/orcid.png)
Publié dansThe Journal of clinical investigation, vol. 116, no. 7, p. 1886-1901
Date de publication2006-07
Date de mise en ligne2006-06-22
Résumé
Mots-clés
- Animals
- Chromones / metabolism
- Diet
- Eating / drug effects
- Female
- Hypoglycemic Agents / pharmacology
- Hypothalamus / cytology
- Hypothalamus / metabolism
- Insulin / metabolism
- Leptin / metabolism
- Male
- Membrane Potentials / drug effects
- Mice
- Mice, Knockout
- Morpholines / metabolism
- Neurons / cytology
- Neurons / drug effects
- Neurons / metabolism
- Obesity
- PTEN Phosphohydrolase / genetics
- PTEN Phosphohydrolase / metabolism
- Phosphatidylinositol 3-Kinases / metabolism
- Phosphatidylinositol Phosphates / metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Potassium Channels / metabolism
- Pro-Opiomelanocortin / metabolism
- Second Messenger Systems / physiology
- Tolbutamide / pharmacology
Structure d'affiliation Pas une publication de l'UNIGE
Groupe de recherche
Citation (format ISO)
PLUM, Leona et al. Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. In: The Journal of clinical investigation, 2006, vol. 116, n° 7, p. 1886–1901. doi: 10.1172/JCI27123
Fichiers principaux (1)
Article (Published version)
![accessLevelPublic](assets/images/access-level-free.png)
Identifiants
- PID : unige:171538
- DOI : 10.1172/JCI27123
- PMID : 16794735
- PMCID : PMC1481658
ISSN du journal0021-9738