Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
Published inNature, vol. 449, no. 7159, p. 228-232
Publication date2007-09-13
First online date2007-08-29
Abstract
Keywords
- Adenosine Triphosphate / biosynthesis
- Adenosine Triphosphate / metabolism
- Animals
- Diabetes Mellitus, Type 2 / metabolism
- Diabetes Mellitus, Type 2 / physiopathology
- Dietary Fats / administration & dosage
- Dietary Fats / pharmacology
- Glucose / metabolism
- Homeostasis
- Humans
- Ion Channels / antagonists & inhibitors
- Ion Channels / genetics
- Ion Channels / metabolism
- Iridoid Glycosides
- Iridoids / pharmacology
- Mice
- Mice, Obese
- Mice, Transgenic
- Mitochondrial Proteins / antagonists & inhibitors
- Mitochondrial Proteins / genetics
- Mitochondrial Proteins / metabolism
- Neurons / drug effects
- Neurons / metabolism
- Neurons / pathology
- Obesity / chemically induced
- Obesity / metabolism
- Obesity / physiopathology
- Potassium Channels, Inwardly Rectifying / genetics
- Potassium Channels, Inwardly Rectifying / metabolism
- Pro-Opiomelanocortin / metabolism
- Uncoupling Protein 2
Affiliation Not a UNIGE publication
Research group
Citation (ISO format)
PARTON, Laura E et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. In: Nature, 2007, vol. 449, n° 7159, p. 228–232. doi: 10.1038/nature06098
Main files (1)
Article (Published version)
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Identifiers
- PID : unige:171527
- DOI : 10.1038/nature06098
- PMID : 17728716
ISSN of the journal0028-0836