Scientific article
Open access

Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation

Published inNeurobiology of aging, vol. 111, p. 24-34
Publication date2022-03
First online date2021-11-20

The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of noninvasive stimulation over these networks in 45 patients (AD and bvFTD) who received either anodal (target network: DMN in AD, SN in bvFTD) or cathodal stimulation (target network: SN in AD, DMN in bvFTD). We evaluated changes in clinical, cognitive, functional and structural connectivity, and perfusion measures. In both patient groups, cathodal stimulation was followed by behavioral improvement, whereas anodal stimulation led to cognitive improvement. Neither functional connectivity nor perfusion showed significant effects. A significant interaction between DMN and SN functional connectivity changes and stimulation protocol was reported in AD. These results suggest a protocol-dependent response, whereby the protocols studied show divergent effects on cognitive and clinical measures, along with a divergent modulatory pattern of connectivity in AD.

Trial registration: ClinicalTrials.gov NCT03422250.

  • Alzheimer's disease
  • Default mode network
  • Frontotemporal dementia
  • Network stimulation
  • Salience network
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / physiopathology
  • Alzheimer Disease / therapy
  • Behavior
  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain / physiopathology
  • Cognition
  • Executive Function
  • Female
  • Frontotemporal Dementia / diagnosis
  • Frontotemporal Dementia / physiopathology
  • Frontotemporal Dementia / therapy
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nerve Net / pathology
  • Nerve Net / physiopathology
  • Transcranial Direct Current Stimulation / methods
Citation (ISO format)
PINI, Lorenzo et al. Brain network modulation in Alzheimer’s and frontotemporal dementia with transcranial electrical stimulation. In: Neurobiology of aging, 2022, vol. 111, p. 24–34. doi: 10.1016/j.neurobiolaging.2021.11.005
Main files (1)
Article (Published version)
Secondary files (1)
ISSN of the journal0197-4580

Technical informations

Creation11/16/2022 1:06:28 PM
First validation06/05/2023 2:33:01 PM
Update time06/05/2023 2:33:01 PM
Status update06/05/2023 2:33:01 PM
Last indexation08/31/2023 11:42:47 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack