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Scientific article
Review
English

An Overview of Cytokine Release Syndrome and Other Side Effects of CAR-T Cell Therapy

Published inPraxis, vol. 112, no. 3, p. 189-193
Publication date2023-03
First online date2023-03-01
Abstract

Oncology has been rapidly evolving over the past decade with tremendous therapeutic development. Engineered cell therapies such as chimeric antigen receptor (CAR)-T cells are increasingly used in daily practice, and provided a paradigm change especially for hematological malignancies. Their development is a scientific and technological achievement, but their toxicities can be life-threatening. As their utilization expands, better understanding of pathophysiology leads to better management. In this article we present a general overview of cell-therapy toxicities and their management.

enggerfre
Keywords
  • Cytokine release syndrome
  • Immuneffektorzell-assoziiertes Neurotoxizitätssyndrom
  • Syndrome de libération cytokinique
  • Zelltherapien
  • Zytokinfreisetzungssyndrom
  • Cell therapies
  • Chimeric antigen receptor
  • Chimärer Antigenrezeptor
  • Immune effector cell-associated neurotoxicity syndrome
  • Récepteur d’antigène chimérique
  • Syndrome de neurotoxicité associé aux cellules effectrices du système immunitaire
  • Thérapies cellulaires
  • Humans
  • Receptors, Chimeric Antigen / therapeutic use
  • Cytokine Release Syndrome / etiology
  • Cytokine Release Syndrome / therapy
  • Cell- and Tissue-Based Therapy
  • Hematologic Neoplasms / therapy
Citation (ISO format)
GENOUD, Vassilis, MIGLIORINI, Denis. An Overview of Cytokine Release Syndrome and Other Side Effects of CAR-T Cell Therapy. In: Praxis, 2023, vol. 112, n° 3, p. 189–193. doi: 10.1024/1661-8157/a003980
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Article (Published version)
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ISSN of the journal1661-8157
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