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Article scientifique
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A practical approach to pediatric liver transplantation in hepatoblastoma and hepatocellular carcinoma

Publié dansHepatoma research, vol. 7, 59
Date de publication2021
Date de mise en ligne2021-07-14
Résumé

Progressively, as chemotherapy has become more effective, more children with liver malignancies are amenable to liver transplantation, and indications have expanded from a limited range of cases (mostly hepatoblastoma) to a range of other unresectable malignant liver tumors; as a result, more children with hepatocellular carcinoma are also now proposed to transplantation, even and often outside the Milan criteria, for a cure. Recent series have highlighted that patient and graft survivals after transplantation for hepatoblastoma and hepatocellular carcinoma have improved in the last decade. Although consensus has not yet been reached about transplantation as a possible cure for other tumor types than hepatoblastoma and hepatocellular carcinoma, liver transplantation, generally speaking, has become an important pillar in the management of pediatric liver malignancies. Remaining limitations and inquiries relate to patient selection (in term of selection criteria considering the risk of recurrence), the role and usefulness of chemotherapy after transplantation, or the best immunosuppression strategy to both protect renal function and improve outcome. Although some prospective studies are on the way regarding these aspects, more studies are needed to explore this rapidly changing aspect of care.

eng
Mots-clés
  • Pediatric liver transplantation
  • Hepatoblastoma
  • Hepatocellular carcinoma
Citation (format ISO)
CALINESCU-TULEASCA, Ana Maria et al. A practical approach to pediatric liver transplantation in hepatoblastoma and hepatocellular carcinoma. In: Hepatoma research, 2021, vol. 7, p. 59. doi: 10.20517/2394-5079.2021.26
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Article (Published version)
Identifiants
ISSN du journal2394-5079
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Informations techniques

Création03/10/2022 08:48:02
Première validation22/05/2023 18:03:14
Heure de mise à jour22/05/2023 18:03:14
Changement de statut22/05/2023 18:03:14
Dernière indexation01/02/2024 10:07:03
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