Scientific article
Open access

Diabète de type MODY : une entité souvent méconnue

Other title[MODY type diabetes: an often-misunderstood entity]
Published inRevue médicale suisse, vol. 17, no. 741, p. 1062-1066
Publication date2021-06-02
First online date2021-06-02

MODY diabetes, for Maturity Onset Diabetes of the Young, is a form of monogenic diabetes characterized by a typical onset before the age of 25 years, the lack of autoimmunity against the b cells of the pancreas, a preserved β cells function and an autosomal dominant mode of inheritance. This type of diabetes constitutes 2 to 5% of all cases of diabetes but remains often undiagnosed. Nearly 15 MODY subtypes have been identified to date. The 3 most common subtypes are caused by mutations in the genes encoding glucokinase, HNF1a and HNF4a, and account for approximately 80% of all MODY cases. Carrying out a genetic test can thus make it possible to make the diagnosis of MODY diabetes and to set up an appropriate treatment. In this article we will discuss these 3 main MODY sub-type, although there are other forms, which may be characterized by associated specific organ damage.

  • Adult
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / genetics
  • Glucokinase / genetics
  • Hepatocyte Nuclear Factor 4 / genetics
  • Humans
  • Mutation
Citation (ISO format)
CAIRONI, Verdiana et al. Diabète de type MODY : une entité souvent méconnue. In: Revue médicale suisse, 2021, vol. 17, n° 741, p. 1062–1066. doi: 10.53738/REVMED.2021.17.741.1062
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Article (Published version)
ISSN of the journal1660-9379

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