Book chapter
English

Selecting the most promising local treatments: retrospective treatment outcome surveys and reverse pharmacology

PublisherLondon : Elsevier Academic Press
EditionElsevier Academic Press
Publication date2022-10-15
First online date2022-04-08
Abstract

The research process called \reverse pharmacology\ aims to help users of traditional medicine plants make safer and more effective choices. The first step is to inquire about the patient’s condition and progress after using local therapeutic products. Once a product has been selected, the second step is to test the hypothesis of efficacy. Indeed, reports of healing are not sufficient as evidence. Thus, clinical studies are organized first in increasing doses, then in randomized controlled trials. For quality control and development of new drugs, the last phase of reverse pharmacology is the pharmaceutical analysis of the products, looking for the active substances and the mechanism of action. The final product can take several forms: a new \improved\ phytomedicine, advice on home treatments for the targeted disease, or a lead for conventional pharmaceutical development. In all cases, the principal objective remains the improvement of the quality of care in the community.

Keywords
  • Metabolomic approaches
  • Pharmacokinetics
  • Reverse pharmacology
  • Population surveys
  • Ethnopharmacology
Citation (ISO format)
HOURIET, Joëlle, WOLFENDER, Jean-Luc, GRAZ, Bertrand. Selecting the most promising local treatments: retrospective treatment outcome surveys and reverse pharmacology. In: Medicinal plants as anti-infectives - current knowledge and new perspectives. Chassagne, François (Ed.). London : Elsevier Academic Press, 2022. doi: 10.1016/B978-0-323-90999-0.00003-3
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Book chapter (Published version)
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Identifiers
ISBN978-0-323-90999-0
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