Scientific article
Open access

Kinetics of disappearance and appearance of isoagglutinins A and B after ABO-incompatible hematopoietic stem cell transplantation

Published inBone marrow transplantation, vol. 57, no. 9, p. 1405-1410
Publication date2022-09
First online date2022-06-25

ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT) can be complicated by poor red cell engraftment and hemolysis, both mediated by isoagglutinins. Anecdotally, isoagglutinins indicates an activation of donor's immunity or even relapse. Consequently, the routine monitoring of isoagglutinins could help physicians to predict the risk of complications. The purpose of this study is to investigate the time to disappearance and appearance of isoagglutinins after ABO-incompatible allogeneic HSCT. In a one-year follow-up, data of 136 ABO-incompatible hematopoietic stem cell (HSC) allogeneic transplanted patients were studied, of which 60 had major, 61 minor and 15 bidirectional incompatibility. Survival analyses were conducted and association with hematological diseases, HLA-compatibility and transplantation strategy was investigated. We observed a disappearance of isoagglutinin A in 82.0% of cases at one year with a median and 75th percentile of 38.4 and 138.6 days, respectively. For isoagglutinin B, these same values were 96.4%, 15.9 and 29.1 days, respectively. The appearance of isoagglutinin A occurred in 10.7% of cases. Disappearance of isoagglutinin A was significantly slower in patients with myeloid diseases compared to other diseases. The results of this study provide useful values to detect early risks of preventable immunohematological complications and possibly, in exceptional cases, relapse.

  • ABO Blood-Group System
  • Blood Group Incompatibility
  • Chronic Disease
  • Hematopoietic Stem Cell Transplantation / methods
  • Humans
  • Kinetics
  • Recurrence
Citation (ISO format)
LEMAIRE, Baptiste et al. Kinetics of disappearance and appearance of isoagglutinins A and B after ABO-incompatible hematopoietic stem cell transplantation. In: Bone marrow transplantation, 2022, vol. 57, n° 9, p. 1405–1410. doi: 10.1038/s41409-022-01737-z
Main files (1)
Article (Published version)
Secondary files (6)
ISSN of the journal0268-3369

Technical informations

Creation10/05/2022 9:45:00 AM
First validation10/05/2022 9:45:00 AM
Update time03/16/2023 10:51:33 AM
Status update03/16/2023 10:51:30 AM
Last indexation02/01/2024 9:40:28 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack