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Scientific article
Review
English

Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa

Published inCurrent opinion in microbiology, vol. 41, p. 15-20
Publication date2018-02
First online date2017-12-19
Abstract

Pseudomonas aeruginosa acute and chronic infections are of great concern to human health, especially in hospital settings. It is currently assumed that P. aeruginosa has two antagonistic pathogenic strategies that parallel two different lifestyles; free-living cells are predominantly cytotoxic and induce an acute inflammatory reaction, while biofilm-forming communities cause refractory chronic infections. Recent findings suggest that the planktonic-to-sessile transition is a complex, reversible and overall dynamic differentiation process. Here, we examine how the Gac/Rsm regulatory cascade, a key player in this lifestyle switch, endows P. aeruginosa with both a permissive lifecycle in nature and flexible virulence strategy during infection.

eng
Keywords
  • Animals
  • Bacterial Infections / classification
  • Bacterial Infections / microbiology
  • Bacterial Proteins / metabolism
  • Biofilms
  • Gene Expression Regulation, Bacterial
  • Host-Pathogen Interactions
  • Humans
  • Mice
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / metabolism
  • Pseudomonas aeruginosa / pathogenicity
  • Virulence
  • Virulence Factors
Affiliation Not a UNIGE publication
Citation (ISO format)
VALENTINI, Martina et al. Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa. In: Current opinion in microbiology, 2018, vol. 41, p. 15–20. doi: 10.1016/j.mib.2017.11.006
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Article (Submitted version)
Identifiers
ISSN of the journal1369-5274
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15downloads

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