Genetic regulation of RNA splicing in human pancreatic islets
ContributorsAtla, Goutham; Bonàs-Guarch, Silvia; Cuenca-Ardura, Mirabai; Beucher, Anthony; Crouch, Daniel J. M.; Garcia-Hurtado, Javier; Moran, Ignasi; Irimia, Manuel; Prasad, Rashmi B.; Gloyn, Anna L.; Marselli, Lorella; Suleiman, Mara; Berney, Thierry; de Koning, Eelco J. P.; Kerr-Conte, Julie; Pattou, Francois; Todd, John A.; Piemonti, Lorenzo; Ferrer, Jorge ; the T2DSystems Consortium
Published inGenome biology, vol. 23, no. 1, 196
Publication date2022-09-15
First online date2022-09-15
Abstract
Keywords
- Beta cells
- CTRB2
- Diabetes pathophysiology
- G-protein signaling
- Pancreatic beta-cells
- Pancreatic islets
- Quantitative trait loci
- RNA splicing
- Senescence
- TWAS
- Type 1 diabetes
- Type 2 diabetes
- Diabetes Mellitus, Type 1 / genetics
- Diabetes Mellitus, Type 1 / metabolism
- Diabetes Mellitus, Type 2 / genetics
- Exodeoxyribonucleases / genetics
- Exodeoxyribonucleases / metabolism
- Humans
- Islets of Langerhans / metabolism
- Proinsulin / genetics
- Proinsulin / metabolism
- Protein Isoforms / genetics
- RNA Splicing
- RNA, Long Noncoding / metabolism
Affiliation entities
Research groups
Funding
- European Commission - Expanding the genetic etiological and diagnostic spectrum of monogenic diabetes mellitus [789055]
- UK Research and Innovation - Targeting etiologic molecular mechanisms to treat human diabetes [MR/L02036X/1]
- European Commission - Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes [667191]
- European Commission - Computational and functional annotation of genomic elements during development of the model vertebrate zebrafish [643062]
- European Commission - Human Cell Atlas of the Pancreas [874710]
- Wellcome Trust - Bridging the gap from type 2 diabetes genetics to functional mechanisms of disease. [095101]
- Wellcome Trust - Defining mechanisms for pancreatic beta-cell dysfunction in type 2 diabetes [200837]
- Wellcome Trust - A systematic approach to understanding the biology underpinning GWAS hits. [106130]
- Wellcome Trust - Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics [203141]
Citation (ISO format)
ATLA, Goutham et al. Genetic regulation of RNA splicing in human pancreatic islets. In: Genome biology, 2022, vol. 23, n° 1, p. 196. doi: 10.1186/s13059-022-02757-0
Main files (1)
Article (Published version)
Secondary files (15)
Identifiers
- PID : unige:166264
- DOI : 10.1186/s13059-022-02757-0
- PMID : 36109769
- PMCID : PMC9479353
ISSN of the journal1474-7596