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Liver-ultrasound based motion modelling to estimate 4D dose distributions for lung tumours in scanned proton therapy

Publié dansPhysics in medicine and biology, vol. 65, no. 23, 235050
Date de publication2020-12-21
Date de mise en ligne2020-12-21
Résumé

Motion mitigation strategies are crucial for scanned particle therapy of mobile tumours in order to prevent geometrical target miss and interplay effects. We developed a patient-specific respiratory motion model based on simultaneously acquired time-resolved volumetric MRI and 2D abdominal ultrasound images. We present its effects on 4D pencil beam scanned treatment planning and simulated dose distributions. Given an ultrasound image of the liver and the diaphragm, principal component analysis and Gaussian process regression were applied to infer dense motion information of the lungs. 4D dose calculations for scanned proton therapy were performed using the estimated and the corresponding ground truth respiratory motion; the differences were compared by dose difference volume metrics. We performed this simulation study on 10 combined CT and 4DMRI data sets where the motion characteristics were extracted from 5 healthy volunteers and fused with the anatomical CT data of two lung cancer patients. Median geometrical estimation errors below 2 mm for all data sets and maximum dose differences of = 43.2% and = 16.3% were found. Moreover, it was shown that abdominal ultrasound imaging allows to monitor organ drift. This study demonstrated the feasibility of the proposed ultrasound-based motion modelling approach for its application in scanned proton therapy of lung tumours.

eng
Mots-clés
  • Four-Dimensional Computed Tomography / methods
  • Humans
  • Liver / diagnostic imaging
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / radiotherapy
  • Magnetic Resonance Imaging / methods
  • Movement
  • Proton Therapy / methods
  • Radiotherapy Planning, Computer-Assisted / methods
  • Respiration
  • Ultrasonography / methods
Citation (format ISO)
GIGER, Alina et al. Liver-ultrasound based motion modelling to estimate 4D dose distributions for lung tumours in scanned proton therapy. In: Physics in medicine and biology, 2020, vol. 65, n° 23, p. 235050. doi: 10.1088/1361-6560/abaa26
Fichiers principaux (2)
Article (Accepted version)
accessLevelPublic
Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal0031-9155
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Informations techniques

Création21/09/2022 16:02:00
Première validation21/09/2022 16:02:00
Heure de mise à jour16/03/2023 08:38:31
Changement de statut16/03/2023 08:38:28
Dernière indexation01/02/2024 09:02:57
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