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Dendritic Branch-constrained N-Methyl-d-Aspartate Receptor-mediated Spikes Drive Synaptic Plasticity in Hippocampal CA3 Pyramidal Cells

Published inNeuroscience, vol. 489, p. 57-68
Publication date2022-05
Abstract

N-methyl-d-aspartate receptor-mediated ( spikes can be causally linked to the induction of synaptic long-term potentiation (LTP) in hippocampal and cortical pyramidal cells. However, it is unclear if they regulate plasticity at a local or global scale in the dendritic tree. Here, we used dendritic patch-clamp recordings and calcium imaging to investigate the integrative properties of single dendrites of hippocampal CA3 cells. We show that local hyperpolarization of a single dendritic segment prevents NMDA spikes, their associated calcium transients, as well as LTP in a branch-specific manner. This result provides direct, causal evidence that the single dendritic branch can operate as a functional unit in regulating CA3 pyramidal cell plasticity.

eng
Keywords
  • CA3
  • LTP
  • Dendrites
  • Dendritic spike
  • Hippocampus
  • Plasticity
Citation (ISO format)
BRANDALISE, Federico et al. Dendritic Branch-constrained N-Methyl-d-Aspartate Receptor-mediated Spikes Drive Synaptic Plasticity in Hippocampal CA3 Pyramidal Cells. In: Neuroscience, 2022, vol. 489, p. 57–68. doi: 10.1016/j.neuroscience.2021.10.002
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ISSN of the journal0306-4522
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Creation09/26/2022 2:44:00 PM
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