Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals

Quintard, Adrien; Alexakis, Alexandre

doi:10.1039/c1cc11967b

Scientific article

English

Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals

ContributorsQuintard, Adrien; Alexakis, Alexandre

Published inChemical communications, vol. 47, no. 25, p. 7212-7214

Publication date2011

Abstract

An unprecedented intermolecular iminium/enamine Michael addition on enals has been developed by taking advantage of the high reactivity of vinyl sulfones. This powerful organocascade allows for the rapid construction of attractive synthons in high enantioselectivities (typically 99% ee).

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

QUINTARD, Adrien, ALEXAKIS, Alexandre. Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals. In: Chemical communications, 2011, vol. 47, n° 25, p. 7212–7214. doi: 10.1039/c1cc11967b

Article (Published version)

Identifiers

PID : unige:16317
DOI : 10.1039/c1cc11967b

Commercial URLhttp://xlink.rsc.org/?DOI=c1cc11967b

Journal ISSN1359-7345

539views

0downloads

Creation20/06/2011 09:46:00

First validation20/06/2011 09:46:00

Update time14/03/2023 16:52:20

Status update14/03/2023 16:52:20

Last indexation29/10/2024 18:11:34

Archive ouverte UNIGE

Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals

An unprecedented intermolecular iminium/enamine Michael addition on enals has been developed by taking advantage of the high reactivity of vinyl sulfones. This powerful organocascade allows for the rapid construction of attractive synthons in high enantioselectivities (typically 99% ee).

Technical informations