Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals

Quintard, Adrien; Alexakis, Alexandre

doi:10.1039/c1cc11967b

Scientific article

English

Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals

ContributorsQuintard, Adrien; Alexakis, Alexandre

Published inChemical communications, vol. 47, no. 25, p. 7212-7214

Publication date2011

Abstract

An unprecedented intermolecular iminium/enamine Michael addition on enals has been developed by taking advantage of the high reactivity of vinyl sulfones. This powerful organocascade allows for the rapid construction of attractive synthons in high enantioselectivities (typically 99% ee).

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

QUINTARD, Adrien, ALEXAKIS, Alexandre. Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals. In: Chemical communications, 2011, vol. 47, n° 25, p. 7212–7214. doi: 10.1039/c1cc11967b

Article (Published version)

Identifiers

PID : unige:16317
DOI : 10.1039/c1cc11967b

Commercial URLhttp://xlink.rsc.org/?DOI=c1cc11967b

ISSN of the journal1359-7345

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Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals

An unprecedented intermolecular iminium/enamine Michael addition on enals has been developed by taking advantage of the high reactivity of vinyl sulfones. This powerful organocascade allows for the rapid construction of attractive synthons in high enantioselectivities (typically 99% ee).

Technical informations