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Scientific article
OA Policy
English

Versatility in the acquisition of energy and carbon sources by the Apicomplexa

Contributors

Polonais, Valérie; Soldati-Favre, Dominique

Published in

Biology of the cell, vol. 102, no. 8, p. 435-445

Publication date

2010

Abstract

Members of the phylum Apicomplexa are motile and rapidly dividing intracellular parasites, able to occupy a large spectrum of niches by infecting diverse hosts and invading various cell types. As obligate intracellular parasites, most apicomplexans only survive for a short period extracellularly, and, during this time, have a high energy demand to power gliding motility and invasion into new host cells. Similarly, these fast-replicating intracellular parasites are critically dependent on host-cell nutrients as energy and carbon sources, noticeably for the extensive membrane biogenesis imposed during growth and division. To access host-cell metabolites, the apicomplexans Toxoplasma gondii and Plasmodium falciparum have evolved strategies that exquisitely reflect adaptation to their respective niches. In the present review, we summarize and compare some recent findings regarding the energetic metabolism and carbon sources used by these two genetically tractable apicomplexans during host-cell invasion and intracellular growth and replication.

Keywords

  • Animals
  • Carbon/metabolism
  • Energy Metabolism
  • Erythrocytes/parasitology
  • Host-Parasite Interactions
  • Humans
  • Lipids/biosynthesis
  • Metabolic Networks and Pathways
  • Plasmodium falciparum/metabolism
  • Protozoan Proteins/metabolism
  • Toxoplasma/metabolism

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

POLONAIS, Valérie, SOLDATI-FAVRE, Dominique. Versatility in the acquisition of energy and carbon sources by the Apicomplexa. In: Biology of the cell, 2010, vol. 102, n° 8, p. 435–445. doi: 10.1042/BC20100005

Main files (1)

Article (Accepted version)

Identifiers

Journal ISSN

0248-4900
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1614downloads

Technical informations

Creation

23/05/2011 09:24:00

First validation

23/05/2011 09:24:00

Update

14/03/2023 16:52:16

Status update

14/03/2023 16:52:16

Last indexation

29/10/2024 18:11:03
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