Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
ContributorsLötscher, Jonas; Marti Lindez, Adria-Arnau; Kirchhammer, Nicole; Cribioli, Elisabetta; Giordano, Greta; Trefny, Marcel P; Lenz, Markus; Rothschild, Sacha I; Strati, Paolo; Künzli, Marco; Lotter, Claudia; Schenk, Susanne H; Dehio, Philippe; Löliger, Jordan; Litzler, Ludivine; Schreiner, David; Koch, Victoria; Page, Nicolas; Lee, Dahye; Grählert, Jasmin; Kuzmin, Dmitry; Burgener, Anne-Valérie; Merkler, Doron; Pless, Miklos; Balmer, Maria L; Reith, Walter; Huwyler, Jörg; Irving, Melita; King, Carolyn G; Zippelius, Alfred; Hess, Christoph
Published inCell, vol. 185, no. 4, p. 585-602.e29
Publication date2022-02-17
First online date2022-01-13
Abstract
Keywords
- CAR T cells
- Mg2+
- T cell engaging antibodies
- Co-stimulation/LFA-1
- Immune control
- Integration of microenvironment and T cell function
- Magnesium
- Memory CD8 T cells
- Microenvironment
- Tumor-specific T cells
Funding
- Swiss National Science Foundation - The role of free Magnesium as second messenger in T cell subpopulations [323530_171148]
- Swiss National Science Foundation - Serine metabolism and T cell migration [323530_183980]
- Swiss National Science Foundation - Reprogramming of acetate metabolism in CD8+ T cells during re-call responses [PMPDP3_171261]
- Swiss National Science Foundation - Immunometabolic sensing of bacterial metabolites driving diet-induced obesity [PCEFP3_194618]
- Novartis Foundation - [17C141]
- Swiss National Science Foundation - Genome-wide CRISPR screen to identify genes involved in T cell dysfunction and novel targets for cancer immunotherapy [320030_188576]
- Swiss National Science Foundation - Role of glucose and serine metabolism in regulating the CD8+ T cell memory response [31003A_172848]
- Swiss National Science Foundation - The role of the endoplasmic reticulum in regulating T cell (dys-)function [310030_192677]
Citation (ISO format)
LÖTSCHER, Jonas et al. Magnesium sensing via LFA-1 regulates CD8<sup>+</sup> T cell effector function. In: Cell, 2022, vol. 185, n° 4, p. 585–602.e29. doi: 10.1016/j.cell.2021.12.039
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Article (Published version)
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Identifiers
- PID : unige:161319
- DOI : 10.1016/j.cell.2021.12.039
- PMID : 35051368
ISSN of the journal0092-8674