As they are gaining new users, climate change mitigation scenarios are playing an increasing role in transitions to Net Zero. One promising practice is the analysis of scenario ensembles. Here we argue that this practice has the potential to bring new and more robust insights compared to the use of single scenarios. Yet, several significant challenges have to be addressed. We identify key methodological challenges, and existing methods and applications that have been or can be used to address them within a three-step approach: (i) pre-processing the ensemble, (ii) either selecting a few scenarios or analyzing the full ensemble, and (iii) providing users with efficient access to the information.