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Scientific article
Review
Open access
English

PET/CT-Based Salvage Radiotherapy for Recurrent Prostate Cancer After Radical Prostatectomy: Impact on Treatment Management and Future Directions

Published inFrontiers in oncology, vol. 11, 742093
Publication date2021
First online date2021-08-31
Abstract

Biochemical recurrence is a clinical situation experienced by 20 to 40% of prostate cancer patients treated with radical prostatectomy (RP). Prostate bed (PB) radiation therapy (RT) remains the mainstay salvage treatment, although it remains non-curative for up to 30% of patients developing further recurrence. Positron emission tomography with computed tomography (PET/CT) using prostate cancer-targeting radiotracers has emerged in the last decade as a new-generation imaging technique characterized by a better restaging accuracy compared to conventional imaging. By adapting targeting of recurrence sites and modulating treatment management, implementation in clinical practice of restaging PET/CT is challenging the established therapeutic standards born from randomized controlled trials. This article reviews the potential impact of restaging PET/CT on changes in the management of recurrent prostate cancer after RP. Based on PET/CT findings, it addresses potential adaptation of RT target volumes and doses, as well as use of androgen-deprivation therapy (ADT). However, the impact of such management changes on the oncological outcomes of PET/CT-based salvage RT strategies is as yet unknown.

eng
Keywords
  • PET/CT
  • PSMA
  • Choline
  • Fluciclovine
  • Oligometastatic
  • Prostate cancer
  • Radiotherapy
  • Relapse
Citation (ISO format)
LE GUEVELOU, Jennifer et al. PET/CT-Based Salvage Radiotherapy for Recurrent Prostate Cancer After Radical Prostatectomy: Impact on Treatment Management and Future Directions. In: Frontiers in oncology, 2021, vol. 11, p. 742093. doi: 10.3389/fonc.2021.742093
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ISSN of the journal2234-943X
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