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Scientific article
English

Absence of risk of sarcopenia protects cancer patients from fatigue

Published inEuropean journal of clinical nutrition, vol. 76, p. 206-211
Publication date2022-02
First online date2021-05-13
Abstract

Background: Cancer and its treatments often lead to sarcopenia and fatigue. However, whether these factors are associated remains unproven.

Objective: To evaluate whether the risk of sarcopenia predicts the presence of fatigue.

Methods: A cross-sectional study was completed and included 198 cancer patients of both sexes, undergoing in- and outpatient treatment. The Strength, Assistance for walking, Rise from a chair, Climb stairs, and Falls (SARC-F) and the Functional Assessment of Cancer Therapy Fatigue (FACT-F) were used to assess the risk of sarcopenia and the presence of fatigue, respectively. The cut-off values used to identify the risk of sarcopenia and the severity of fatigue scale were SARC-F ≥ 4 and Fatigue <34, respectively. Logistic regression analysis was performed to evaluate the association between SARC-F and the FACT-F.

Results: Out of 198 patients, 35% were at risk of sarcopenia and of these 87% had fatigue. Patients at risk of sarcopenia had lower scores in the FACT-F subscales, lower handgrip strength, lower performance status, were mostly hospitalized and were sedentary. Logistic regression analysis revealed that patients with SARC-F < 4 had a lower risk of fatigue in both models, crude (OR: 0.83; CI 95% [0.79-0.88], p < 0.0001) as well as adjusted for age, gender, BMI, physical activity, current use of alcoholic beverages, smoking, performance status, cancer type, clinical setting and use of supplements (OR: 0.87; CI 95% [0.81-0.92], p < 0.0001).

Conclusion: In patients with cancer, 35% presented risk of sarcopenia and of these 87% had fatigue. In addition, the absence of sarcopenia was considered protective against fatigue.

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Citation (ISO format)
BARRETO, Cleidiana S. et al. Absence of risk of sarcopenia protects cancer patients from fatigue. In: European journal of clinical nutrition, 2022, vol. 76, p. 206–211. doi: 10.1038/s41430-021-00931-4
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ISSN of the journal0954-3007
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Creation01/10/2022 10:45:00 AM
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