With better risk assessments, improvements in treatments and optimized supportive care more than 87% of the children with cancer become long-term survivors in Switzerland. Many studies have demonstrated that this enlarging population has a lifelong increased risk of morbidity and mortality associated with the underlying disease and the therapies received. Altogether, two thirds of the survivors will present at least one chronic health condition during their life and for one-third of them, the condition will be severe or life threatening as late effect of their treatment. In this context, a structured long-term follow-up is needed. The aim of this article is to give a global vision of the current situation in Switzerland concerning the different care models proposed to childhood cancer survivors and to provide recommendations for appropriate transition and long-term follow-up care.