Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity: Results of the European PanCareLIFE cohort study
ContributorsLanger, Thorsten; Clemens, Eva; Broer, Linda; Maier, Lara; Uitterlinden, André G; de Vries, Andrica C H; van Grotel, Martine; Pluijm, Saskia F M; Binder, Harald; Mayer, Benjamin; von dem Knesebeck, Annika; Byrne, Julianne; van Dulmen-den Broeder, Eline; Crocco, Marco; Grabow, Desiree; Kaatsch, Peter; Kaiser, Melanie; Spix, Claudia; Kenborg, Line; Winther, Jeanette F; Rechnitzer, Catherine; Hasle, Henrik; Kepak, Tomas; van der Kooi, Anne-Lotte F; Kremer, Leontien C; Kruseova, Jarmila; Bielack, Stefan; Sorg, Benjamin; Hecker-Nolting, Stefanie; Kuehni, Claudia E; Ansari Djaberi, Marc Georges; Kompis, Martin; van der Pal, Heleen; Parfitt, Ross; Deuster, Dirk; Matulat, Peter; Tillmanns, Amelie; Tissing, Wim J E; Beck, Jörn D; Elsner, Susanne; Am Zehnhoff-Dinnesen, Antoinette; van den Heuvel-Eibrink, Marry M; Zolk, Oliver; PanCareLIFE consortium
Published inEuropean journal of cancer, vol. 138, p. 212-224
Publication date2020-10
First online date2020-09-06
Abstract
Keywords
- Adverse drug reaction
- Anti-neoplastic drugs
- Cancer survivors
- Childhood cancer
- Cisplatin: carboplatin
- Drug-induced ototoxicity
- Genetic markers
- Multicenter cohort study
- Pharmacogenetics
- Adolescent
- Age of Onset
- Antineoplastic Agents / adverse effects
- Cancer Survivors
- Carboplatin / adverse effects
- Child
- Child, Preschool
- Cisplatin / adverse effects
- Cross-Sectional Studies
- Europe
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Hearing / drug effects
- Hearing Loss, Sensorineural / chemically induced
- Hearing Loss, Sensorineural / genetics
- Hearing Loss, Sensorineural / physiopathology
- Humans
- Infant
- Infant, Newborn
- Male
- Neoplasms / drug therapy
- Organic Cation Transporter 2 / genetics
- Ototoxicity
- Pharmacogenomic Testing
- Pharmacogenomic Variants
- Polymorphism, Single Nucleotide
- Prospective Studies
- Retrospective Studies
- Risk Assessment
- Risk Factors
Research group
Funding
- European Commission - PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood [602030]
- Swiss Cancer Research Foundation - [4157-02-2017]
- Swiss Cancer League - [3412-02-2014]
Citation (ISO format)
LANGER, Thorsten et al. Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity: Results of the European PanCareLIFE cohort study. In: European journal of cancer, 2020, vol. 138, p. 212–224. doi: 10.1016/j.ejca.2020.07.019
Main files (1)
Article (Published version)
Secondary files (3)
Identifiers
- PID : unige:159449
- DOI : 10.1016/j.ejca.2020.07.019
- PMID : 32905960
ISSN of the journal0959-8049