Altered neuroaxonal integrity in schizophrenia and major depressive disorder assessed with neurofilament light chain in serum

Bavato, Francesco; Cathomas, Flurin; Klaus, Federica; Gütter, Karoline; Barro, Christian; Maceski, Aleksandra; Seifritz, Erich; Kuhle, Jens; Kaiser, Stefan; Quednow, Boris B

doi:10.1016/j.jpsychires.2021.05.072

Scientific article

Open access

English

Altered neuroaxonal integrity in schizophrenia and major depressive disorder assessed with neurofilament light chain in serum

ContributorsBavato, Francesco; Cathomas, Flurin; Klaus, Federica; Gütter, Karoline; Barro, Christian; Maceski, Aleksandra; Seifritz, Erich; Kuhle, Jens; Kaiser, Stefan; Quednow, Boris B

Published inJournal of Psychiatric Research, vol. 140, p. 141-148

Publication date2021

Abstract

Schizophrenia (SZ) and major depressive disorders (MDD) have been frequently linked to anatomical brain alterations. However, the relationship between brain pathology, inflammation and clinical symptoms in these disorders is still unclear. Thus, by applying novel blood markers of neuroaxonal integrity such as neurofilament light chain (NfL), we can now address main issues in psychiatric research and potentially offer innovative diagnostic tools toward better clinical characterizations and monitoring in both SZ and MDD.

Keywords

Biomarkers
Brain
Depressive Disorder, Major
Humans
Intermediate Filaments
Schizophrenia
Cognition
Depression
Inflammation
Neurofilament light chain
Schizophrenia

Affiliation

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research group

Psychopathologie clinique et expérimentale (987)

Citation (ISO format)

BAVATO, Francesco et al. Altered neuroaxonal integrity in schizophrenia and major depressive disorder assessed with neurofilament light chain in serum. In: Journal of Psychiatric Research, 2021, vol. 140, p. 141–148. doi: 10.1016/j.jpsychires.2021.05.072