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Scientific article
Open access
English

Distinct fMRI patterns colocalized in the cingulate cortex underlie the after-effects of cognitive control on pain

Published inNeuroImage, vol. 217, 116898
Publication date2020-08
First online date2020-05-04
Abstract

Demanding tasks can influence following behaviors but the underlying mechanisms remain largely unclear. In the present functional magnetic resonance imaging (fMRI) study, we used multivariate pattern analyses (MVPA) to compare patterns of brain activity associated with pain in response to noxious stimuli administered after a task requiring cognitive control (Stroop) and evaluate their functional interaction based on a mediation analysis model. We found that performing a difficult cognitive task leads to subsequent increases in pain and pain-related multivariate responses across the brain and within the anterior mid-cingulate cortex (aMCC). Moreover, an aMCC pattern predictive of task performance was further reactivated during pain and predicted ensuing increases in pain-related brain responses. This suggests functional interactions between distinct but partly co-localized neural networks underlying executive control and pain. These findings offer a new perspective on the functional role of the cingulate cortex in pain and cognition and provide a promising framework to investigate dynamical interactions between partly overlapping brain networks.

eng
Funding
  • Swiss National Science Foundation - Impact de la déplétion des ressources cognitives sur la douleur
Citation (ISO format)
SILVESTRINI, Nicolas et al. Distinct fMRI patterns colocalized in the cingulate cortex underlie the after-effects of cognitive control on pain. In: NeuroImage, 2020, vol. 217, p. 116898. doi: 10.1016/j.neuroimage.2020.116898
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Article (Published version)
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ISSN of the journal1053-8119
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