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Scientific article
English

Circadian Lipidomics: Analysis of Lipid Metabolites Around the Clock

Published inMethods in Molecular Biology, vol. 2130, p. 169-183
Publication date2021
Abstract

Lipidomics has been defined as the large-scale analysis of lipids in organelles, cells, tissues, or whole organisms. Including the temporal aspects of lipid metabolic changes into this analysis allows to access yet another important aspect of lipid regulation. The resulting methodology, circadian lipidomics, has thus emerged as a novel tool to address the enormous complexity, which is present among cellular lipids. Here, we describe how mass spectrometry-based circadian lipidomics can be applied to study the impact of peripheral clocks on lipid metabolism in human primary cells and tissues, exemplified by studies in human pancreatic islets and skeletal myotubes.

Keywords
  • Cells, Cultured
  • Circadian Rhythm
  • Humans
  • Islets of Langerhans/metabolism
  • Lipid Metabolism
  • Lipidomics/methods
  • Mass Spectrometry/methods
  • Muscle, Skeletal/metabolism
  • Lipid metabolism
  • Lipidomics
  • Circadian clock
  • Human skeletal muscle
  • Human primary myotubes
  • Human pancreatic islets
Citation (ISO format)
LOIZIDES-MANGOLD, Ursula Elfriede, PETRENKO, Volodymyr, DIBNER, Charna. Circadian Lipidomics: Analysis of Lipid Metabolites Around the Clock. In: Methods in Molecular Biology, 2021, vol. 2130, p. 169–183. doi: 10.1007/978-1-0716-0381-9_13
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Article (Published version)
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ISSN of the journal1064-3745
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Creation08/25/2021 7:09:00 AM
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