Efficacy of pragmatic same-day ring prophylaxis for adult individuals exposed to SARS-CoV-2 in Switzerland (COPEP): protocol of an open-label cluster randomised trial

Smit, Mikaëla; Marinosci, Annalisa; Nicoletti, Giovanni Jacopo; Perneger, Thomas; Ragozzino, Silvio; Andrey, Diego Olivier; Stoeckle, Marcel; Jacquerioz, Frédérique Aline; Lebowitz, Dan; Agoritsas, Thomas; Meyer, Benjamin; Spechbach, Hervé; Salamun, Julien; Back, Moritz; Schaubhut, Carla; Fuchs, Simon; Decosterd, Laurent; Battegay, Manuel; Guessous, Idris; Chappuis, François; Kaiser, Laurent; Labhardt, Niklaus D; Calmy, Alexandra

doi:10.1136/bmjopen-2020-040110

Scientific article

English

Efficacy of pragmatic same-day ring prophylaxis for adult individuals exposed to SARS-CoV-2 in Switzerland (COPEP): protocol of an open-label cluster randomised trial

Published inBMJ Open, vol. 10, no. 11, e040110

Publication date2020

Abstract

Lopinavir/ritonavir (LPV/r) has been proposed as repurposed drugs for pre-exposure and postexposure prophylaxis as well as therapy of COVID-19. Coronavirus postexposure prophylaxis (COPEP) trial aims at assessing their efficacy as postexposure ring-prophylaxis among adults exposed to SARS-CoV-2.

Keywords

Antiviral Agents/therapeutic use
Betacoronavirus
COVID-19
Coronavirus Infections/prevention & control
Drug Combinations
Humans
Lopinavir/therapeutic use
Pandemics/prevention & control
Pneumonia
Viral/prevention & control
Post-Exposure Prophylaxis/methods
Randomized Controlled Trials as Topic
Ritonavir/therapeutic use
SARS-CoV-2
Switzerland

Affiliation entities

Research groups

Funding

Swiss National Science Foundation - Evaluation of a simplified strategy for the long-term management of HIV infection: a non-inferiority, randomized, controlled, open-label clinical trial (The SIMPL-HIV Trial) [33IC30_166819]

Citation (ISO format)

SMIT, Mikaëla et al. Efficacy of pragmatic same-day ring prophylaxis for adult individuals exposed to SARS-CoV-2 in Switzerland (COPEP): protocol of an open-label cluster randomised trial. In: BMJ Open, 2020, vol. 10, n° 11, p. e040110. doi: 10.1136/bmjopen-2020-040110