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Scientific article
Letter
English

Asymmetric alkylation of N-acylsultams: a general route to enantiomerically pure, crystalline C(α,α)-disubstituted carboxylic acid derivatives

Published inTetrahedron Letters, vol. 30, no. 41, p. 5603-5606
Publication date1989
Abstract

Successive treatment of acylsultams with nBuLi or NHMDS and primary alkyl halides, followed by crystallization, gave pure C(α)-alkylation products and, via their non-destructive cleavage, enantiomerically pure alcohols or carboxylic acids. Alkylation of acylsultams 2 with primary alkyl halides gave pure 4 which was cleaved to enantiomerically pure alcohols (5) or carboxylic acids (6).

Citation (ISO format)
VON OPPOLZER, Wolfgang, MORETTI, Robert, THOMI, Silvia Béatrice. Asymmetric alkylation of N-acylsultams: a general route to enantiomerically pure, crystalline C(α,α)-disubstituted carboxylic acid derivatives. In: Tetrahedron Letters, 1989, vol. 30, n° 41, p. 5603–5606. doi: 10.1016/S0040-4039(01)93810-9
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ISSN of the journal0040-4039
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