Effect of tranexamic acid by baseline risk of death in acute bleeding patients: a meta-analysis of individual patient-level data from 28 333 patients

Ageron, Francois-Xavier; Gayet-Ageron, Angèle; Ker, Katharine; Coats, Timothy J; Shakur-Still, Haleema; Roberts, Ian; The Antifibrinolytics Trials Collaboration

doi:10.1016/j.bja.2020.01.020

Scientific article

Meta-analysis

Open access

English

Effect of tranexamic acid by baseline risk of death in acute bleeding patients: a meta-analysis of individual patient-level data from 28 333 patients

ContributorsAgeron, Francois-Xavier; Gayet-Ageron, Angèle; Ker, Katharine; Coats, Timothy J; Shakur-Still, Haleema; Roberts, Ian; The Antifibrinolytics Trials Collaboration

Published inBritish Journal of Anaesthesia, vol. 124, no. 6, p. 676-683

Publication date2020

Abstract

Early administration of the antifibrinolytic drug tranexamic acid reduces death from bleeding in trauma and postpartum haemorrhage. We examined how the effectiveness and safety of antifibrinolytic drugs varies by the baseline risk of death as a result of bleeding.

Keywords

Acute Disease
Adult
Antifibrinolytic Agents/therapeutic use
Female
Hemorrhage/drug therapy
Humans
Male
Randomized Controlled Trials as Topic
Risk
Tranexamic Acid/therapeutic use
Young Adult

Affiliation

Research group

Epidémiologie clinique et biostatistique (115)

Citation (ISO format)

AGERON, Francois-Xavier et al. Effect of tranexamic acid by baseline risk of death in acute bleeding patients: a meta-analysis of individual patient-level data from 28 333 patients. In: British Journal of Anaesthesia, 2020, vol. 124, n° 6, p. 676–683. doi: 10.1016/j.bja.2020.01.020