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Scientific article
English

Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance

Published inAntimicrobial Agents and Chemotherapy, vol. 51, no. 1, p. 369-371
Publication date2007
Abstract

Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.

Keywords
  • Alleles
  • Antifungal Agents/pharmacology
  • Candida/drug effects/enzymology/genetics
  • Cloning, Molecular
  • Cytosine Deaminase/genetics
  • DNA, Fungal/chemistry/genetics
  • Drug Resistance, Fungal/genetics
  • Fluconazole/pharmacology
  • Flucytosine/pharmacology
  • Fluorouracil/pharmacology
  • Fungal Proteins/genetics
  • Genetic Complementation Test
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Mutation
  • Pentosyltransferases/genetics
  • Plasmids/genetics
  • Sequence Analysis, DNA
Affiliation Not a UNIGE publication
Citation (ISO format)
PAPON, Nicolas et al. Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. In: Antimicrobial Agents and Chemotherapy, 2007, vol. 51, n° 1, p. 369–371. doi: 10.1128/AAC.00824-06
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0066-4804
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