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Molecular pathway of influenza pan-neuraminidase inhibitor resistance in an immunocompromised patient

Abed, Yacine
Checkmahomed, Liva
Carbonneau, Julie
Venable, Marie-Christine
Fage, Clément
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Published in Antiviral Therapy. 2019, vol. 24, no. 8, p. 581-587
Abstract Neuraminidase (NA) inhibitors (NAIs), including oseltamivir and zanamivir, play an important therapeutic role against influenza infections in immunocompromised patients. In such settings, however, NAI therapy may lead to the emergence of resistance involving mutations within the influenza surface genes. The aim of this study was to investigate the evolution of NA and haemagglutinin (HA) genes of influenza A(H1N1)pdm09 virus in an immunocompromised patient receiving oseltamivir then zanamivir therapies.
Keywords AgedAntiviral Agents/administration & dosage/pharmacology/therapeutic useDrug Resistance, Multiple, ViralEnzyme Inhibitors/administration & dosage/pharmacology/therapeutic useHematopoietic Stem Cell TransplantationHumansImmunocompromised HostInfluenza A Virus, H1N1 Subtype/drug effects/geneticsInfluenza, Human/drug therapy/virologyMaleNeuraminidase/antagonists & inhibitorsOseltamivir/administration & dosage/pharmacology/therapeutic useTransplant RecipientsZanamivir/administration & dosage/pharmacology/therapeutic use
PMID: 32031540
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Research groups Groupe Laurent Kaiser (virologie clinique) (668)
Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
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ABED, Yacine et al. Molecular pathway of influenza pan-neuraminidase inhibitor resistance in an immunocompromised patient. In: Antiviral Therapy, 2019, vol. 24, n° 8, p. 581-587. doi: 10.3851/IMP3344 https://archive-ouverte.unige.ch/unige:147186

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Deposited on : 2021-01-13

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