Diagnosis of epilepsy after first seizure. Introducing the SWISS FIRST study

Jin, Baudouin Zongxin; De Stefano, Pia; Petroulia, Valentina; Rummel, Christian; Kiefer, Claus; Reyes, Mauricio; Schindler, Kaspar; van Mierlo, Pieter; Seeck, Margitta; Wiest, Roland

doi:10.1177/2514183X20939448

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Title		Diagnosis of epilepsy after first seizure. Introducing the SWISS FIRST study
Authors		Jin, Baudouin Zongxin De Stefano, Pia Petroulia, Valentina Rummel, Christian Kiefer, Claus Reyes, Mauricio Schindler, Kaspar van Mierlo, Pieter Seeck, Margitta Wiest, Roland show all authors [1 - 10]
Published in		Clinical and Translational Neuroscience. 2020
Abstract		Diagnosis of epilepsy after a first unprovoked seizure is possible according to the guidelines by the International League Against Epilepsy, if the risk recurrence of a second unprovoked seizure is exceeding 60%. However, this cutoff constitutes only a proxy depending on the patients' history, magnetic resonance imaging (MRI), and electroencephalography (EEG) findings but nevertheless also from the treating neurologists' individual experience. In a Switzerland-wide observational study, we aim to recruit patients that were admitted to the emergency department with the referral diagnosis of a first and unprovoked seizure. We make use of optimized MRI protocols to identify potential structural epileptogenic lesions, introduce new imaging-based markers of epileptogenecity, and use most recent postprocessing methods as automatic morphometry, spike map analysis, and functional connectivity. With these diagnostic tools, we aim to segregate patients that present with epileptic seizures versus mimicks and non-epileptic seizures and stratify for every finding in MRI and EEG its predictive value for a second unprovoked seizure. These findings shall support neurologists to calculate and not only estimate the seizure recurrence rate in future.
Keywords		Epilepsy — Neuroimaging — Automatic morphometry — Functional connectivity — Spike maps
Identifiers		DOI: 10.1177/2514183X20939448
Full text		Article (Published version) (432 Kb) - Free access Other version: http://journals.sagepub.com/doi/10.1177/2514183X20939448
Structures		Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Research group		Epilepsie et Chirurgie (149)
Project		Swiss National Science Foundation: Sinergia
Citation (ISO format)		JIN, Baudouin Zongxin et al. Diagnosis of epilepsy after first seizure. Introducing the SWISS FIRST study. In: Clinical and Translational Neuroscience, 2020. doi: 10.1177/2514183X20939448 https://archive-ouverte.unige.ch/unige:144693