Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions

Vokali, Efthymia; Yu, Shann S; Hirosue, Sachiko; Rinçon-Restrepo, Marcela; Do Valle Duraes, Fernanda; Scherer, Stefanie; Corthésy-Henrioud, Patricia; Kilarski, Witold W; Mondino, Anna; Zehn, Dietmar; Hugues, Stéphanie; Swartz, Melody A

doi:10.1038/s41467-019-14127-9

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
Authors		Vokali, Efthymia Yu, Shann S Hirosue, Sachiko Rinçon-Restrepo, Marcela Do Valle Duraes, Fernanda Scherer, Stefanie Corthésy-Henrioud, Patricia Kilarski, Witold W Mondino, Anna Zehn, Dietmar Hugues, Stéphanie Swartz, Melody A show all authors [1 - 12]
Published in		Nature communications. 2020, vol. 11, no. 1, 538
Abstract		Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8+ T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8+ T cells is unknown. Here, we show that while many proliferating LEC-educated T cells enter early apoptosis, the remainders comprise a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and stem cell-like memory T cells. In vivo, these memory cells preferentially home to lymph nodes and display rapid proliferation and effector differentiation following memory recall, and can protect mice against a subsequent bacterial infection. These findings introduce a new immunomodulatory role for LECs in directly generating a memory-like subset of quiescent yet antigen-experienced CD8+ T cells that are long-lived and can rapidly differentiate into effector cells upon inflammatory antigenic challenge.
Keywords		Animals — CD8-Positive T-Lymphocytes/immunology — Cell Proliferation — Endothelial Cells/immunology/physiology — Gene Expression Profiling — Immunologic Memory — Mice — Inbred C57BL — Mice — Transgenic
Identifiers		DOI: 10.1038/s41467-019-14127-9 PMID: 31988323
Full text		Article (Published version) (2.3 MB) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Pathologie et immunologie (906)
Citation (ISO format)		VOKALI, Efthymia et al. Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions. In: Nature Communications, 2020, vol. 11, n° 1, p. 538. doi: 10.1038/s41467-019-14127-9 https://archive-ouverte.unige.ch/unige:144199