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Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions

Vokali, Efthymia
Yu, Shann S
Hirosue, Sachiko
Rinçon-Restrepo, Marcela
Scherer, Stefanie
Corthésy-Henrioud, Patricia
Kilarski, Witold W
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Published in Nature communications. 2020, vol. 11, no. 1, 538
Abstract Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8+ T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8+ T cells is unknown. Here, we show that while many proliferating LEC-educated T cells enter early apoptosis, the remainders comprise a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and stem cell-like memory T cells. In vivo, these memory cells preferentially home to lymph nodes and display rapid proliferation and effector differentiation following memory recall, and can protect mice against a subsequent bacterial infection. These findings introduce a new immunomodulatory role for LECs in directly generating a memory-like subset of quiescent yet antigen-experienced CD8+ T cells that are long-lived and can rapidly differentiate into effector cells upon inflammatory antigenic challenge.
Keywords AnimalsCD8-Positive T-Lymphocytes/immunologyCell ProliferationEndothelial Cells/immunology/physiologyGene Expression ProfilingImmunologic MemoryMiceInbred C57BLMiceTransgenic
PMID: 31988323
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Article (Published version) (2.3 MB) - public document Free access
Research group Pathologie et immunologie (906)
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VOKALI, Efthymia et al. Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions. In: Nature Communications, 2020, vol. 11, n° 1, p. 538. doi: 10.1038/s41467-019-14127-9 https://archive-ouverte.unige.ch/unige:144199

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Deposited on : 2020-11-04

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