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Scientific article
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Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions

Published inNature Communications, vol. 11, no. 1, 538
Publication date2020
Abstract

Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8+ T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8+ T cells is unknown. Here, we show that while many proliferating LEC-educated T cells enter early apoptosis, the remainders comprise a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and stem cell-like memory T cells. In vivo, these memory cells preferentially home to lymph nodes and display rapid proliferation and effector differentiation following memory recall, and can protect mice against a subsequent bacterial infection. These findings introduce a new immunomodulatory role for LECs in directly generating a memory-like subset of quiescent yet antigen-experienced CD8+ T cells that are long-lived and can rapidly differentiate into effector cells upon inflammatory antigenic challenge.

Keywords
  • Animals
  • CD8-Positive T-Lymphocytes/immunology
  • Cell Proliferation
  • Endothelial Cells/immunology/physiology
  • Gene Expression Profiling
  • Immunologic Memory
  • Mice
  • Inbred C57BL
  • Mice
  • Transgenic
Citation (ISO format)
VOKALI, Efthymia et al. Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions. In: Nature Communications, 2020, vol. 11, n° 1, p. 538. doi: 10.1038/s41467-019-14127-9
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Article (Published version)
Identifiers
ISSN of the journal2041-1723
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Creation10/23/2020 2:02:00 PM
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