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Scientific article
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Hyperthyroidism and bone mineral density: Dissecting the causal association with Mendelian randomization analysis

Publication date2020
Abstract

Introduction: Untreated hyperthyroidism is associated with accelerated bone turnover, low bone mineral density (BMD) and increased susceptibility to fragility fractures. Although treatment appears to improve or even reverse some of these adverse skeletal effects, there is limited guidance on routine BMD assessment in hyperthyroid patients following treatment. By using Mendelian randomization (MR) analysis, we aimed to assess the causal association of hyperthyroid thyroid states with BMD and fractures using the UK Biobank.

Keywords
  • Bone
  • Bone density
  • Fractures
  • Graves disease
  • Hyperthyroidism
  • Investigations
  • Thyroid
Citation (ISO format)
DESHMUKH, Harshal et al. Hyperthyroidism and bone mineral density: Dissecting the causal association with Mendelian randomization analysis. In: Clinical Endocrinology, 2020. doi: 10.1111/cen.14330
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Article (Published version)
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Identifiers
ISSN of the journal0300-0664
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Technical informations

Creation10/06/2020 11:15:00 AM
First validation10/06/2020 11:15:00 AM
Update time03/15/2023 10:56:54 PM
Status update03/15/2023 10:56:53 PM
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