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Title

Hyperthyroidism and bone mineral density: Dissecting the causal association with Mendelian randomization analysis
Authors
Deshmukh, Harshal
Papageorgiou, Maria
Aye, Mo
England, James
Abdalla, Mohammed
Sathyapalan, Thozhukat
Published in Clinical Endocrinology. 2020
Abstract Introduction: Untreated hyperthyroidism is associated with accelerated bone turnover, low bone mineral density (BMD) and increased susceptibility to fragility fractures. Although treatment appears to improve or even reverse some of these adverse skeletal effects, there is limited guidance on routine BMD assessment in hyperthyroid patients following treatment. By using Mendelian randomization (MR) analysis, we aimed to assess the causal association of hyperthyroid thyroid states with BMD and fractures using the UK Biobank.
Keywords Bone — Bone density — Fractures — Graves disease — Hyperthyroidism — Investigations — Thyroid
Identifiers
PMID: 32947644
Full text
Article (Published version) (703 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: https://onlinelibrary.wiley.com/doi/10.1111/cen.14330
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Research group Génétique des ostéoporoses (544)
Citation
(ISO format) 		DESHMUKH, Harshal et al. Hyperthyroidism and bone mineral density: Dissecting the causal association with Mendelian randomization analysis. In: Clinical Endocrinology, 2020. doi: 10.1111/cen.14330 https://archive-ouverte.unige.ch/unige:144118

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Deposited on : 2020-11-04

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