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Title

COVID-19 infection and treatment with hydroxychloroquine cause severe haemolysis crisis in a patient with glucose-6-phosphate dehydrogenase deficiency
Authors
Beauverd, Yan
Adam, Yannick
Assouline, Benjamin
Samii, Kaveh
Published in European Journal of Haematology. 2020, vol. 105, no. 3, p. 357-359
Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited genetic disorder caused by red cell enzymatic defects and is associated with haemolytic crisis when patients are exposed to oxidative agents (fava beans, drugs, infections). Hydroxychloroquine is suspected to trigger haemolytic crisis in G6PD-deficient patients, and off-label administration of this drug to patients infected with the novel coronavirus (SARS-CoV-2) could cause concern. We report here the first case of severe haemolytic crisis in a patient with G6PD deficiency, initiated by severe COVID-19 infection and hydroxychloroquine use. With worldwide spread of COVID-19, especially in regions with a high prevalence of G6PD deficiency, our case should alert physicians to this possible correlation.
Keywords Coronavirus — COVID-19 — G6PD deficiency — Haemolysis — Hydroxychloroquine — SARS-CoV-2 — Aged — Betacoronavirus — Comorbidity — Coronavirus Infections/complications/drug therapy/epidemiology — Glucosephosphate Dehydrogenase Deficiency/complications/epidemiology — Hemolysis/drug effects — Humans — Hydroxychloroquine/adverse effects/therapeutic use — Male — Pandemics — Pneumonia, Viral/drug therapy/epidemiology
Identifiers
PMID: 32324284
Full text
Article (Published version) (432 Kb) - public document Free access
Other version: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264743/
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences
Research group Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
Citation
(ISO format) 		BEAUVERD, Yan et al. COVID-19 infection and treatment with hydroxychloroquine cause severe haemolysis crisis in a patient with glucose-6-phosphate dehydrogenase deficiency. In: European Journal of Haematology, 2020, vol. 105, n° 3, p. 357-359. doi: 10.1111/ejh.13432 https://archive-ouverte.unige.ch/unige:143939

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Deposited on : 2020-11-02

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