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Circadian clocks make metabolism run

Published in Journal of Molecular Biology. 2020, vol. 432, no. 12, p. 3680-3699
Abstract Most organisms adapt to the 24-h cycle of the Earth's rotation by anticipating the time of the day through light-dark cycles. The internal time-keeping system of the circadian clocks has been developed to ensure this anticipation. The circadian system governs the rhythmicity of nearly all physiological and behavioral processes in mammals. In this review, we summarize current knowledge stemming from rodent and human studies on the tight interconnection between the circadian system and metabolism in the body. In particular, we highlight recent advances emphasizing the roles of the peripheral clocks located in the metabolic organs in regulating glucose, lipid, and protein homeostasis at the organismal and cellular levels. Experimental disruption of circadian system in rodents is associated with various metabolic disturbance phenotypes. Similarly, perturbation of the clockwork in humans is linked to the development of metabolic diseases. We discuss recent studies that reveal roles of the circadian system in the temporal coordination of metabolism under physiological conditions and in the development of human pathologies.
PMID: 31996313
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Article (Published version) (1.2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Endocrinologie et horloge circadienne (948)
Swiss National Science Foundation: 31003A_166700
Swiss National Science Foundation: 310030_184708
(ISO format)
SINTUREL, Flore, PETRENKO, Volodymyr, DIBNER, Charna. Circadian clocks make metabolism run. In: Journal of Molecular Biology, 2020, vol. 432, n° 12, p. 3680-3699. doi: 10.1016/j.jmb.2020.01.018 https://archive-ouverte.unige.ch/unige:139236

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Deposited on : 2020-08-11

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