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Prospective cohort study on the predictors of fall risk in 119 patients with bilateral vestibulopathy

Dobbels, Bieke
Lucieer, Florence
Mertens, Griet
Gilles, Annick
Moyaert, Julie
van de Heyning, Paul
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Published in PLOS ONE. 2020, vol. 15, no. 3, e0228768
Abstract Objectives: To identify predictive factors for falls in patients with bilateral vestibulopathy (BV). Specific variables contributing to the general work-up of a vestibular patient were compared between BV patients experiencing falls and those who did not. Design: Prospective multi-centric cohort study. Setting: Department of Otorhinolaryngology & Head and Neck Surgery at two tertiary referral centers: Antwerp University Hospital and Maastricht University Medical Center. Participants: In total, 119 BV patients were included. BV diagnosis was defined in accordance with the diagnostic BV criteria, established by the Bárány Society in 2017. Main outcome measures: Patients were divided into fallers and non-fallers, depending on the experience of one or more falls in the preceding 12 months. Residual vestibular function on caloric testing, rotatory chair testing, video head impulse test (vHIT) and cervical vestibular evoked myogenic potentials (cVEMP) was evaluated as a predictive factor for falls. Furthermore, hearing function (speech perception in noise (SPIN)), sound localization performance, etiology, disease duration, sport practice, scores on the Dizziness Handicap Inventory (DHI) and the Oscillopsia Severity Questionnaire (OSQ) were compared between fallers and non-fallers. Results: Forty-five (39%) patients reported falls. In a sub-analysis in the patients recruited at UZA (n = 69), 20% experienced three or more falls and three patients (4%) suffered from severe fall-related injuries. The DHI score and the OSQ score were significantly higher in fallers. Residual vestibular function, SPIN, sound localization performance, etiology, disease duration, age and sport practice did not differ between fallers and non-fallers. Conclusions: Falls and (severe) fall-related injuries are frequent among BV patients. A DHI score > 47 and an OSQ score > 27.5 might be indicative for BV patients at risk for falls, with a sensitivity of 70% and specificity of 60%. Residual vestibular function captured by single vestibular tests (vHIT, calorics, rotatory chair, cVEMP) or by overall vestibular function defined as the number of impaired vestibular sensors are not suitable to distinguish fallers and non-fallers in a BV population.
Keywords Accidental Falls / statistics & numerical dataAdultAgedAged, 80 and overAudiometry, Speech / methodsBilateral Vestibulopathy / complicationsBilateral Vestibulopathy / diagnosisBilateral Vestibulopathy / physiopathologyCaloric Tests / methodsCohort StudiesFemaleHead Impulse TestHumansMaleMiddle AgedPostural BalanceProspective StudiesRisk AssessmentSensitivity and SpecificitySurveys and QuestionnairesTertiary Care CentersVestibular Evoked Myogenic PotentialsYoung Adult
PMID: 32150553
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Other version: https://dx.plos.org/10.1371/journal.pone.0228768
Research group Neuroprothèses sensorielles pour la restitution de l'audition et l'équilibre (268)
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DOBBELS, Bieke et al. Prospective cohort study on the predictors of fall risk in 119 patients with bilateral vestibulopathy. In: PLOS ONE, 2020, vol. 15, n° 3, p. e0228768. doi: 10.1371/journal.pone.0228768 https://archive-ouverte.unige.ch/unige:137148

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Deposited on : 2020-06-16

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