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Evolution, Composition, Assembly, and Function of the Conoid in Apicomplexa

Publication date2020
Abstract

The phylum Apicomplexa has been defined by the presence of the apical complex, a structure composed of secretory organelles and specific cytoskeletal elements. A conspicuous feature of the apical complex in many apicomplexans is the conoid, a hollow tapered barrel structure composed of tubulin fibers. In Toxoplasma gondii, the apical complex is a central site of convergence for calcium-related and lipid-mediated signaling pathways that coordinate conoid protrusion, microneme secretion, and actin polymerization, to initiate gliding motility. Through cutting-edge technologies, great progress has recently been made in discovering the structural subcomponents and proteins implicated in the biogenesis and stability of the apical complex and, in turn, these discoveries have shed new light on the function and evolution of this definitive structure.

Keywords
  • Apical complex
  • Conoid
  • Apical polar ring
  • Microtubules
  • Toxoplasma gondii
  • Apicomplexa
Citation (ISO format)
DOS SANTOS PACHECO, Nicolas et al. Evolution, Composition, Assembly, and Function of the Conoid in Apicomplexa. In: Trends in Parasitology, 2020. doi: 10.1016/j.pt.2020.05.001
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Identifiers
ISSN of the journal1471-4922
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Technical informations

Creation06/04/2020 9:37:00 AM
First validation06/04/2020 9:37:00 AM
Update time03/15/2023 10:06:53 PM
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