Learning from the Past: a Review of Clinical Trials Targeting Amyloid, Tau and Neuroinflammation in Alzheimer&#039;s Disease

Ceyzeriat, Kelly; Zilli, Thomas; Millet, Philippe; Frisoni, Giovanni; Garibotto, Valentina; Tournier, Benjamin

doi:10.2174/1567205017666200304085513

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Title		Learning from the Past: a Review of Clinical Trials Targeting Amyloid, Tau and Neuroinflammation in Alzheimer's Disease
Authors		Ceyzeriat, Kelly Zilli, Thomas Millet, Philippe Frisoni, Giovanni Garibotto, Valentina Tournier, Benjamin
Published in		Current Alzheimer research. 2020, vol. 17, p. 1-13
Abstract		Alzheimer's disease (AD) is the most common neurodegenerative disease and cause of dementia. Characterized by amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau, AD pathology has been intensively studied during the last century. After a long series of failed trials of drugs targeting amyloid or Tau deposits, currently hope lies in the positive results of one Phase III trial, highly debated, and on other ongoing trials. In parallel, some approaches target neuroinflammation, another central feature of AD. Therapeutic strategies are initially evaluated on animal models, in which the various drugs have shown effectiveness on the target (decreasing amyloid, Tau and neuroinflammation) and sometimes on cognitive impairment. However, it is important to keep in mind that rodent models have a less complex brain than humans and that the pathology is generally not fully represented. Although they are indispensable tools in the drug discovery process, results obtained from animal models must be viewed with caution. In this review, we focus on the current status of disease modifying therapies targeting amyloid, Tau and neuroinflammation with particular attention on the discrepancy between positive pre-clinical results on animal models and failures in clinical trials.
Keywords		Alzheimer's disease — Therapies — Amyloid load — Tau — Neuroinflammation — Animal models
Identifiers		DOI: 10.2174/1567205017666200304085513 PMID: 32129164
Full text		Article (Published version) (2.5 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984) Neuroimagerie moléculaire en psychiatrie (983) Troubles de mémoire et maladie d'Alzeimer (935)
Citation (ISO format)		CEYZERIAT, Kelly et al. Learning from the Past: a Review of Clinical Trials Targeting Amyloid, Tau and Neuroinflammation in Alzheimer's Disease. In: Current Alzheimer Research, 2020, vol. 17, p. 1-13. doi: 10.2174/1567205017666200304085513 https://archive-ouverte.unige.ch/unige:134004