Scientific article

Extracellular vesicles: Future diagnostic and therapeutic tools for liver disease and regeneration

Published inLiver International, vol. 39, no. 10, p. 1801-1817
Publication date2019

Extracellular vesicles are membrane fragments that can be produced by all cell types. Interactions between extracellular vesicles and various liver cells constitute an emerging field in hepatology and recent evidences have established a role for extracellular vesicles in various liver diseases and physiological processes. Extracellular vesicles originating from liver cells are implicated in intercellular communication and fluctuations of specific circulating extracellular vesicles could constitute new diagnostic tools. In contrast, extracellular vesicles derived from progenitor cells interact with hepatocytes or non-parenchymal cells, thereby protecting the liver from various injuries and promoting liver regeneration. Our review focuses on recent developments investigating the role of various types of extracellular vesicles in acute and chronic liver diseases as well as their potential use as biomarkers and therapeutic tools.

  • Exosome
  • Extracellular vesicle
  • Liver injury
  • Liver regeneration
  • Microparticle
  • Microvesicle
Citation (ISO format)
BALAPHAS, Alexandre et al. Extracellular vesicles: Future diagnostic and therapeutic tools for liver disease and regeneration. In: Liver International, 2019, vol. 39, n° 10, p. 1801–1817. doi: 10.1111/liv.14189
Main files (1)
Article (Published version)
ISSN of the journal1478-3223

Technical informations

Creation07/26/2019 9:57:00 AM
First validation07/26/2019 9:57:00 AM
Update time03/15/2023 9:17:40 PM
Status update03/15/2023 9:17:39 PM
Last indexation10/19/2023 12:19:45 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack