Scientific article

Hepatitis C virus and glucose and lipid metabolism

Published inDiabetes & metabolism, vol. 34, no. 6 Pt 2, p. 692-700
Publication date2008

The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide. Its spectrum of severity, however, varies widely, as does its rate of progression towards cirrhosis. This depends on several host-related cofactors, such as age, gender, alcohol consumption, over weight and co-infections. The objective of this review is to discuss two of these cofactors: steatosis and insulin resistance. Although both may occur independently of HCV, a direct role of HCV infection in their pathogenesis has been reported. Whereas the virus-induced steatosis does not seem to have major clinical consequences, the so-called 'metabolic' steatosis and underlying insulin resistance may not only modify the clinical and histological course of chronic hepatitis C, but may also influence the response to interferon alpha-based therapy.

  • Diabetes Mellitus/epidemiology
  • Disease Progression
  • Fatty Liver/epidemiology/virology
  • Female
  • Hepacivirus
  • Hepatitis C/complications/epidemiology
  • Hepatitis C, Chronic/complications/epidemiology
  • Humans
  • Insulin Resistance
  • Liver Cirrhosis/epidemiology/virology
  • Male
  • Risk Factors
Citation (ISO format)
ALAEI, Mahnaz, NEGRO, Francesco. Hepatitis C virus and glucose and lipid metabolism. In: Diabetes & metabolism, 2008, vol. 34, n° 6 Pt 2, p. 692–700. doi: 10.1016/S1262-3636(08)74606-8
Main files (1)
Article (Accepted version)
ISSN of the journal1262-3636

Technical informations

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