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Title

Hepatitis C virus and glucose and lipid metabolism

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Published in Diabetes & Metabolism. 2008, vol. 34, no. 6 Pt 2, p. 692-700
Abstract The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide. Its spectrum of severity, however, varies widely, as does its rate of progression towards cirrhosis. This depends on several host-related cofactors, such as age, gender, alcohol consumption, over weight and co-infections. The objective of this review is to discuss two of these cofactors: steatosis and insulin resistance. Although both may occur independently of HCV, a direct role of HCV infection in their pathogenesis has been reported. Whereas the virus-induced steatosis does not seem to have major clinical consequences, the so-called 'metabolic' steatosis and underlying insulin resistance may not only modify the clinical and histological course of chronic hepatitis C, but may also influence the response to interferon alpha-based therapy.
Keywords Diabetes Mellitus/epidemiologyDisease ProgressionFatty Liver/epidemiology/virologyFemaleHepacivirusHepatitis C/complications/epidemiologyHepatitis C, Chronic/complications/epidemiologyHumansInsulin ResistanceLiver Cirrhosis/epidemiology/virologyMaleRisk Factors
Stable URL https://archive-ouverte.unige.ch/unige:1287
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PMID: 19195632
Structures
Research group Etudes et traitement de l'hépatite C et B (554)

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Deposited on : 2009-04-01

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