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Scientific article
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Incorporation of GSTA1 genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation

Published inBritish Journal of Clinical Pharmacology, vol. 84, no. 7, p. 1494-1504
Publication date2018
Abstract

The aim of this study is to develop a population pharmacokinetic (PopPK) model for intravenous busulfan in children that incorporates variants of GSTA1, gene coding for the main enzyme in busulfan metabolism.

Keywords
  • Administration
  • Intravenous
  • Area Under Curve
  • Busulfan/administration & dosage/pharmacokinetics
  • Child
  • Preschool
  • Feasibility Studies
  • Female
  • Glutathione Transferase/genetics/metabolism
  • Graft Rejection/immunology/prevention & control
  • Hematopoietic Stem Cell Transplantation/adverse effects
  • Humans
  • Immunosuppressive Agents/administration & dosage/pharmacokinetics
  • Infant
  • Male
  • Models
  • Biological
  • Polymorphism
  • Single Nucleotide
  • Precision Medicine/methods
  • Transplantation Conditioning/methods
  • GSTA1
  • Busulfan
  • Children
  • Polymorphisms
  • Population pharmacokinetics
  • Stem cell transplantation
Citation (ISO format)
NAVA, Tiago et al. Incorporation of GSTA1 genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation. In: British Journal of Clinical Pharmacology, 2018, vol. 84, n° 7, p. 1494–1504. doi: 10.1111/bcp.13566
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0306-5251
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104downloads

Technical informations

Creation11/06/2019 9:03:00 AM
First validation11/06/2019 9:03:00 AM
Update time03/15/2023 6:42:56 PM
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