en
Scientific article
Open access
English

Incorporation of GSTA1 genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation

Published inBritish Journal of Clinical Pharmacology, vol. 84, no. 7, p. 1494-1504
Publication date2018
Abstract

The aim of this study is to develop a population pharmacokinetic (PopPK) model for intravenous busulfan in children that incorporates variants of GSTA1, gene coding for the main enzyme in busulfan metabolism.

Keywords
  • Administration
  • Intravenous
  • Area Under Curve
  • Busulfan/administration & dosage/pharmacokinetics
  • Child
  • Preschool
  • Feasibility Studies
  • Female
  • Glutathione Transferase/genetics/metabolism
  • Graft Rejection/immunology/prevention & control
  • Hematopoietic Stem Cell Transplantation/adverse effects
  • Humans
  • Immunosuppressive Agents/administration & dosage/pharmacokinetics
  • Infant
  • Male
  • Models
  • Biological
  • Polymorphism
  • Single Nucleotide
  • Precision Medicine/methods
  • Transplantation Conditioning/methods
  • GSTA1
  • Busulfan
  • Children
  • Polymorphisms
  • Population pharmacokinetics
  • Stem cell transplantation
Citation (ISO format)
NAVA, Tiago et al. Incorporation of GSTA1 genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation. In: British Journal of Clinical Pharmacology, 2018, vol. 84, n° 7, p. 1494–1504. doi: 10.1111/bcp.13566
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0306-5251
263views
101downloads

Technical informations

Creation06/11/2019 09:03:00
First validation06/11/2019 09:03:00
Update time15/03/2023 18:42:56
Status update15/03/2023 18:42:55
Last indexation17/01/2024 08:43:14
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack