Targeting GLP-1 receptor trafficking to improve agonist efficacy
ContributorsJones, Ben; Buenaventura, Teresa; Kanda, Nisha; Chabosseau, Pauline; Owen, Bryn M; Scott, Rebecca; Goldin, Robert; Angkathunyakul, Napat; Corrêa, Ivan R (Jr); Bosco, Domenico; Johnson, Paul R; Piemonti, Lorenzo; Marchetti, Piero; Shapiro, A M James; Cochran, Blake J; Hanyaloglu, Aylin C; Inoue, Asuka; Tan, Tricia; Rutter, Guy A; Tomas, Alejandra; Bloom, Stephen R
Published inNature Communications, vol. 9, no. 1, 1602
Publication date2018
Abstract
Keywords
- Animals
- Blood Glucose/drug effects
- CHO Cells
- Cell Membrane/drug effects/metabolism
- Cricetulus
- Diabetes Mellitus
- Experimental
- Type 2/blood/drug therapy/pathology
- Endocytosis/drug effects
- Glucagon-Like Peptide 1/metabolism
- Glucagon-Like Peptide-1 Receptor/agonists/metabolism
- HEK293 Cells
- Humans
- Hypoglycemic Agents/pharmacology/therapeutic use
- Insulin/genetics/metabolism
- Insulin-Secreting Cells/drug effects/metabolism
- Male
- Mice
- Inbred C57BL
- Nausea/chemically induced/epidemiology
- Primary Cell Culture
- Protein Transport/drug effects
- RNA
- Small Interfering/metabolism
- Treatment Outcome
Affiliation entities
Research groups
Funding
- Autre - MRC, BBSRC, NIHR, an Integrative Mammalian Biology (IMB) Capacity Building Award
- European Commission - European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs. [241592]
Citation (ISO format)
JONES, Ben et al. Targeting GLP-1 receptor trafficking to improve agonist efficacy. In: Nature Communications, 2018, vol. 9, n° 1, p. 1602. doi: 10.1038/s41467-018-03941-2
Main files (1)
Article (Published version)
Secondary files (2)
Identifiers
- PID : unige:128571
- DOI : 10.1038/s41467-018-03941-2
- PMID : 29686402
Commercial URLhttps://www.nature.com/articles/s41467-018-03941-2
ISSN of the journal2041-1723