en
Scientific article
Open access
English

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

Published inGenes and Development, vol. 14, no. 23, p. 2950-2961
Publication date2000
Abstract

In mammals, circadian oscillators exist not only in the suprachiasmatic nucleus, which harbors the central pacemaker, but also in most peripheral tissues. It is believed that the SCN clock entrains the phase of peripheral clocks via chemical cues, such as rhythmically secreted hormones. Here we show that temporal feeding restriction under light–dark or dark–dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving the phase of cyclic gene expression in the SCN unaffected. Hence, changes in metabolism can lead to an uncoupling of peripheral oscillators from the central pacemaker. Sudden large changes in feeding time, similar to abrupt changes in the photoperiod, reset the phase of rhythmic gene expression gradually and are thus likely to act through a clock-dependent mechanism. Food-induced phase resetting proceeds faster in liver than in kidney, heart, or pancreas, but after 1 wk of daytime feeding, the phases of circadian gene expression are similar in all examined peripheral tissues.

Keywords
  • Circadian clock
  • Restricted feeding
  • SCN
  • Liver
  • Clock genes
  • Mouse
Citation (ISO format)
DAMIOLA, Francesca et al. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. In: Genes and Development, 2000, vol. 14, n° 23, p. 2950–2961. doi: 10.1101/gad.183500
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0890-9369
255views
119downloads

Technical informations

Creation11/20/2019 12:00:00 PM
First validation11/20/2019 12:00:00 PM
Update time03/15/2023 6:24:32 PM
Status update03/15/2023 6:24:31 PM
Last indexation01/17/2024 8:15:05 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack