



![]() |
Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes |
|
Authors | ![]() | |
Published in | Gut. 2016, vol. 65, no. 4, p. 672-682 | |
Abstract | Caveats in the understanding of ribavirin (RBV) mechanisms of action has somehow prevented the development of better analogues able to further improve its therapeutic contribution in interferon (IFN)-based and direct antiviral agent-based regimens for chronic HCV or other indications. Here, we describe a new mechanism by which RBV modulates IFN-stimulated genes (ISGs) and contributes to restore hepatic immune responsiveness. | |
Keywords | Antiviral Agents/pharmacology — Blotting — Western — Cells — Cultured — Enzyme-Linked Immunosorbent Assay — Epigenomics — Gene Expression/drug effects — Hepacivirus/drug effects — Hepatitis C — Chronic — Hepatocytes/drug effects/metabolism — Histone-Lysine N-Methyltransferase/metabolism — Humans — Immunoprecipitation — Interferon-alpha/genetics/pharmacology — RNA — Messenger/drug effects — Real-Time Polymerase Chain Reaction — Ribavirin/pharmacology — Transfection — Viral Load — Virus Replication/drug effects | |
Identifiers | PMID: 26082258 | |
Full text |
![]() ![]() ![]() ![]() |
|
Structures | ||
Research group | Etudes et traitement de l'hépatite C et B (554) | |
Citation (ISO format) | TESTONI, Barbara et al. Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes. In: Gut, 2016, vol. 65, n° 4, p. 672-682. doi: 10.1136/gutjnl-2014-309011 https://archive-ouverte.unige.ch/unige:126405 |