UNIGE document Professional Article
previous document  unige:126405  next document
add to browser collection
Title

Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes

Authors
Testoni, Barbara
Durantel, David
Lebossé, Fanny
Fresquet, Judith
Helle, François
Donato, Maria Francesca
Levrero, Massimo
show hidden authors show all authors [1 - 9]
Published in Gut. 2016, vol. 65, no. 4, p. 672-682
Abstract Caveats in the understanding of ribavirin (RBV) mechanisms of action has somehow prevented the development of better analogues able to further improve its therapeutic contribution in interferon (IFN)-based and direct antiviral agent-based regimens for chronic HCV or other indications. Here, we describe a new mechanism by which RBV modulates IFN-stimulated genes (ISGs) and contributes to restore hepatic immune responsiveness.
Keywords Antiviral Agents/pharmacologyBlottingWesternCellsCulturedEnzyme-Linked Immunosorbent AssayEpigenomicsGene Expression/drug effectsHepacivirus/drug effectsHepatitis CChronicHepatocytes/drug effects/metabolismHistone-Lysine N-Methyltransferase/metabolismHumansImmunoprecipitationInterferon-alpha/genetics/pharmacologyRNAMessenger/drug effectsReal-Time Polymerase Chain ReactionRibavirin/pharmacologyTransfectionViral LoadVirus Replication/drug effects
Identifiers
PMID: 26082258
Full text
Article (Published version) (2.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Supplemental data (2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Etudes et traitement de l'hépatite C et B (554)
Citation
(ISO format)
TESTONI, Barbara et al. Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes. In: Gut, 2016, vol. 65, n° 4, p. 672-682. doi: 10.1136/gutjnl-2014-309011 https://archive-ouverte.unige.ch/unige:126405

25 hits

0 download

Update

Deposited on : 2019-11-18

Export document
Format :
Citation style :