Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes

Testoni, Barbara; Durantel, David; Lebossé, Fanny; Fresquet, Judith; Helle, François; Negro, Francesco; Donato, Maria Francesca; Levrero, Massimo; Zoulim, Fabien

doi:10.1136/gutjnl-2014-309011

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Title		Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes
Authors		Testoni, Barbara Durantel, David Lebossé, Fanny Fresquet, Judith Helle, François Negro, Francesco Donato, Maria Francesca Levrero, Massimo Zoulim, Fabien show all authors [1 - 9]
Published in		Gut. 2016, vol. 65, no. 4, p. 672-682
Abstract		Caveats in the understanding of ribavirin (RBV) mechanisms of action has somehow prevented the development of better analogues able to further improve its therapeutic contribution in interferon (IFN)-based and direct antiviral agent-based regimens for chronic HCV or other indications. Here, we describe a new mechanism by which RBV modulates IFN-stimulated genes (ISGs) and contributes to restore hepatic immune responsiveness.
Keywords		Antiviral Agents/pharmacology — Blotting — Western — Cells — Cultured — Enzyme-Linked Immunosorbent Assay — Epigenomics — Gene Expression/drug effects — Hepacivirus/drug effects — Hepatitis C — Chronic — Hepatocytes/drug effects/metabolism — Histone-Lysine N-Methyltransferase/metabolism — Humans — Immunoprecipitation — Interferon-alpha/genetics/pharmacology — RNA — Messenger/drug effects — Real-Time Polymerase Chain Reaction — Ribavirin/pharmacology — Transfection — Viral Load — Virus Replication/drug effects
Identifiers		DOI: 10.1136/gutjnl-2014-309011 PMID: 26082258
Full text		Article (Published version) (2.7 MB) - Limited access to UNIGE Supplemental data (2 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Etudes et traitement de l'hépatite C et B (554)
Citation (ISO format)		TESTONI, Barbara et al. Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes. In: Gut, 2016, vol. 65, n° 4, p. 672-682. doi: 10.1136/gutjnl-2014-309011 https://archive-ouverte.unige.ch/unige:126405