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Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes

Published inGut, vol. 65, no. 4, p. 672-682
Publication date2016
Abstract

Caveats in the understanding of ribavirin (RBV) mechanisms of action has somehow prevented the development of better analogues able to further improve its therapeutic contribution in interferon (IFN)-based and direct antiviral agent-based regimens for chronic HCV or other indications. Here, we describe a new mechanism by which RBV modulates IFN-stimulated genes (ISGs) and contributes to restore hepatic immune responsiveness.

Keywords
  • Antiviral Agents/pharmacology
  • Blotting
  • Western
  • Cells
  • Cultured
  • Enzyme-Linked Immunosorbent Assay
  • Epigenomics
  • Gene Expression/drug effects
  • Hepacivirus/drug effects
  • Hepatitis C
  • Chronic
  • Hepatocytes/drug effects/metabolism
  • Histone-Lysine N-Methyltransferase/metabolism
  • Humans
  • Immunoprecipitation
  • Interferon-alpha/genetics/pharmacology
  • RNA
  • Messenger/drug effects
  • Real-Time Polymerase Chain Reaction
  • Ribavirin/pharmacology
  • Transfection
  • Viral Load
  • Virus Replication/drug effects
Citation (ISO format)
TESTONI, Barbara et al. Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes. In: Gut, 2016, vol. 65, n° 4, p. 672–682. doi: 10.1136/gutjnl-2014-309011
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Article (Published version)
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Identifiers
ISSN of the journal0017-5749
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