First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9

Gnesin, Silvano; Cicone, Francesco; Mitsakis, Periklis; Van der Gucht, Axel; Baechler, Sébastien; Miralbell, Raymond; Garibotto, Valentina; Zilli, Thomas; Prior, John O

doi:10.1186/s13550-018-0462-9

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9
Authors		Gnesin, Silvano Cicone, Francesco Mitsakis, Periklis Van der Gucht, Axel Baechler, Sébastien Miralbell, Raymond Garibotto, Valentina Zilli, Thomas Prior, John O show all authors [1 - 9]
Published in		EJNMMI Research. 2018, vol. 8, no. 1, p. 108
Abstract		Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer positron emission tomography (PET) protocol. Five male patients with biochemical relapse of prostate adenocarcinoma underwent four whole-body time-of-flight PET/CT scans within 2 h after tracer injection. To be used as input in OLINDA/EXM 2.0, time-integrated activity coefficients were derived from manually drawn regions of interest over the following body regions: brain, thyroid, lungs, heart, liver, gallbladder, spleen, stomach, kidneys, adrenals, red marrow, pancreas, intestines, urinary bladder and whole body. Organ absorbed doses and effective dose (ED) were calculated with OLINDA/EXM 2.0 using the NURBS voxelized phantoms adjusted to the ICRP-89 organ masses and ICRP103 tissue-weighting factors. Additional absorbed dose estimations were performed with OLINDA/EXM 1.1 to be comparable with similar previous publications.
Keywords		68Ga-NODAGA-MJ9 — Biochemical relapse — Bombesin — Dosimetry — GRP antagonist — Gastrin-releasing peptide receptor — OLINDA/EXM — PET/CT — Prostate cancer — Theranostics
Identifiers		DOI: 10.1186/s13550-018-0462-9 PMID: 30543050
Full text		Article (Published version) (997 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research group		Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984)
Citation (ISO format)		GNESIN, Silvano et al. First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9. In: EJNMMI Research, 2018, vol. 8, n° 1, p. 108. doi: 10.1186/s13550-018-0462-9 https://archive-ouverte.unige.ch/unige:126250