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Scientific article
Open access
English

First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9

Published inEJNMMI Research, vol. 8, no. 1, 108
Publication date2018
Abstract

Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer positron emission tomography (PET) protocol. Five male patients with biochemical relapse of prostate adenocarcinoma underwent four whole-body time-of-flight PET/CT scans within 2 h after tracer injection. To be used as input in OLINDA/EXM 2.0, time-integrated activity coefficients were derived from manually drawn regions of interest over the following body regions: brain, thyroid, lungs, heart, liver, gallbladder, spleen, stomach, kidneys, adrenals, red marrow, pancreas, intestines, urinary bladder and whole body. Organ absorbed doses and effective dose (ED) were calculated with OLINDA/EXM 2.0 using the NURBS voxelized phantoms adjusted to the ICRP-89 organ masses and ICRP103 tissue-weighting factors. Additional absorbed dose estimations were performed with OLINDA/EXM 1.1 to be comparable with similar previous publications.

Keywords
  • 68Ga-NODAGA-MJ9
  • Biochemical relapse
  • Bombesin
  • Dosimetry
  • GRP antagonist
  • Gastrin-releasing peptide receptor
  • OLINDA/EXM
  • PET/CT
  • Prostate cancer
  • Theranostics
Citation (ISO format)
GNESIN, Silvano et al. First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9. In: EJNMMI Research, 2018, vol. 8, n° 1, p. 108. doi: 10.1186/s13550-018-0462-9
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Article (Published version)
Identifiers
ISSN of the journal2191-219X
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