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Title

Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study

Authors
Samelson, Elizabeth J
Broe, Kerry E
Xu, Hanfei
Yang, Laiji
Boyd, Steven
Szulc, Pawel
Adachi, Jonathan
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Published in The Lancet Diabetes & Endocrinology. 2019, vol. 7, no. 1, p. 34-43
Abstract Although areal bone mineral density (aBMD) assessed by dual-energy x-ray absorptiometry (DXA) is the clinical standard for determining fracture risk, most older adults who sustain a fracture have T scores greater than –2·5 and thus do not meet the clinical criteria for osteoporosis. Importantly, bone fragility is due to low BMD and deterioration in bone structure. We assessed whether indices of high-resolution peripheral quantitative CT (HR-pQCT) were associated with fracture risk independently of femoral neck aBMD and the Fracture Risk Assessment Tool (FRAX) score.We assessed participants in eight cohorts from the USA (Framingham, Mayo Clinic), France (QUALYOR, STRAMBO, OFELY), Switzerland (GERICO), Canada (CaMos), and Sweden (MrOS). We used Cox proportional hazard ratios (HRs) to estimate the association between HR-pQCT bone indices (per 1 SD of deficit) and incident fracture, adjusting for age, sex, height, weight, and cohort, and then additionally for femoral neck DXA aBMD or FRAX.
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PMID: 30503163
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Supplemental data (687 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: https://linkinghub.elsevier.com/retrieve/pii/S2213858718303085
Structures
Research group Génétique des ostéoporoses (544)
Citation
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SAMELSON, Elizabeth J et al. Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study. In: The Lancet Diabetes & Endocrinology, 2019, vol. 7, n° 1, p. 34-43. doi: 10.1016/S2213-8587(18)30308-5 https://archive-ouverte.unige.ch/unige:126089

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Deposited on : 2019-11-12

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